132452-24-5Relevant articles and documents
Palladium-catalyzed intramolecular α-arylation of aliphatic ketone, formyl, and nitro groups
Muratake, Hideaki,Natsume, Mitsutaka,Nakai, Hiroshi
, p. 11783 - 11803 (2007/10/03)
Intramolecular arylation of properly designed substrates bearing a ketone, formyl, or nitro terminating group was achieved by use of a PdCl 2(Ph3P)2-Cs2CO3 reaction system to form a variety of carbocyclic compounds. Arylation in ketone compounds afforded benzene-annulated bridged or spirocycloalkanone derivatives, depending on the structure of the cyclization precursors. Arylation in formyl compounds occurred at the α-position (α-arylation) or at the carbonyl carbon (carbonyl-arylation) depending on the structure of the cyclization precursors and on the reaction solvent. An α-arylated secondary nitro group was partially transformed to ketone in the manner of the Nef reaction, whereas a tertiary nitro group was partially eliminated to afford a styrene-type olefin. Graphical Abstract
A Novel Palladium-Catalyzed Intramolecular Redox Reaction
Hoegenauer, Klemens,Mulzer, Johann
, p. 1495 - 1497 (2007/10/03)
matrix presented A new type of palladium-catalyzed redox reaction is described, forming enones from 2-(2-bromobenzyl)-ketones with an overall loss of HBr. The scope and limitations of the reaction are demonstrated by a series of cyclic and acyclic substra
Efficient synthesis of 2- and 3-substituted indenes from 2-bromobenzyl bromide through an enolate alkylation/Cr(II)/Ni(II)-mediated carbonyl addition sequence
Halterman, Ronald L.,Zhu, Chengian
, p. 7445 - 7448 (2007/10/03)
An efficient new synthesis of 2- and 3-substituted indenes has been developed based on the nickel-catalyzed chromium(II)-promoted addition of aryl bromides to a tethered ketone carbonyl. Several tethered bromoaryl ketones were prepared through enolate alk
