132474-76-1Relevant academic research and scientific papers
Ruthenium(II)-catalyzed facile synthesis of 3-(phenylamino)-1H-indole-2-carboxylates from anilines and diazo pyruvates promoted by FeCl3
Sajjad, Farrukh,Reddy, Alavala Gopi Krishna,Xing, Dong,Dong, Suzhen,Hu, Wenhao
, (2020/12/07)
An unprecedented synthetic route towards a variety of 3-anilino-1H-indoles is accomplished from diazo pyruvates and anilines via a domino ruthenium-catalyzed annulation and subsequent iron promoted fragmentation and rearrangement. The current strategy was amenable to deliver diversely substituted indole esters, which were subjected to in vitro anti-cancer activity assessment using CCK-8 assay. Compound 4i displayed the best inhibition activity with IC50 value of 0.05 μM, triggering the initiation towards discovering promising lead compounds in the future.
