87223-77-6

Basic information

• Product Name: 3-AMINO-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 3-AMINO-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER;ETHYL 3-AMINO-1H-INDOLE-2-CARBOXYLATE;1H-Indole-2-carboxylicacid,3-amino-,ethylester(9CI);Ethyl 3-amino-2-indolecarboxylate
• CAS NO: 87223-77-6
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.23
• Product Categories: AMINOACID;pharmacetical
• Mol File: 87223-77-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 153-154°C
• Boiling Point: 400.1°C at 760 mmHg
• Flash Point: 195.8°C
• Appearance: /
• Density: 1.288
• Vapor Pressure: 1.3E-06mmHg at 25°C
• Refractive Index: 1.669
• Storage Temp.: 2-8°C
• PKA: 15.70±0.30(Predicted)
• CAS DataBase Reference: 3-AMINO-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER(87223-77-6)
• EPA Substance Registry System: 3-AMINO-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER(87223-77-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 87223-77-6(Hazardous Substances Data)

Usage

General Description

3-Amino-1H-indole-2-carboxylic acid ethyl ester is a chemical compound, likely used in the context of pharmaceutical or chemical research. As an amino acid derivative, it has an ethyl ester attachment, meaning it likely has higher reactivity and could be employed as a building block in more complex compounds. Indole, a component of this chemical, is an aromatic organic compound, which also lends to its reactivity. It has potential biological properties, considering indole's presence in various natural substances and pharmaceuticals. Details such as its exact physical or chemical properties, toxicity, or specific uses, however, are not readily available without further specification or context.

InChI:InChI=1/C11H12N2O2/c1-2-15-11(14)10-9(12)7-5-3-4-6-8(7)13-10/h3-6,13H,2,12H2,1H3

Upstream product

• 1885-29-6 anthranilic acid nitrile 
• 87223-76-5 (2-cyanophenylamino)acetic acid ethyl ester 

Downstream Products

• 143603-78-5 3-{[1-(4-Phenoxy-phenyl)-meth-(E)-ylidene]-amino}-1H-indole-2-carboxylic acid ethyl ester 
• 143603-72-9 3-{[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-amino}-1H-indole-2-carboxylic acid ethyl ester 
• 143603-80-9 3-{[1-(4-Hydroxy-phenyl)-meth-(E)-ylidene]-amino}-1H-indole-2-carboxylic acid ethyl ester 
• 132474-76-1 ethyl 3-(phenylamino)-1H-indole-2-carboxylate 
• 61553-71-7 5H-pyrimido<5,4-b>indole-4-one 
• 110963-29-6 3-Aminoindole-2-carbohydrazide 
• 676601-59-5 1-{4-[2-(3,4-difluoro-phenyl)ethyl]-piperazin-1-yl}-6-nitro-9H-2,4,9-triaza-fluorene 
• 676601-64-2 1-{4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl}-9H-2,4,9-triazafluoren-6-ylamine 

Relevant articles and documents

Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization

A new class of inhibitors of tubulin polymerization based on the 2-alkoxycarbonyl-3-(3′,4′,5′-trimethoxyanilino)indole molecular skeleton was synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization and cell cycle eff

Interleukin-4 gene expression inhibitors

This invention discloses and claims a class of indole and benzo(b)thiophene derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. The compounds of this invention are defined by the Formula (I): wherein X, Y, Z, R1, R2 and R3 are as defined in the specification; or a pharmaceutically acceptable salt thereof. In preferred embodiments of this invention it is also disclosed and claimed that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.

CERTAIN ARYL FUSED PYRROLOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS

The present invention encompasses structures of the formula: STR1 and the pharmaceutically acceptable non-toxic salts thereof wherein: STR2 and X represents hydrogen, halogen, or hydroxy; W represents an aryl group unsubstituted or substituted with