13248-04-9Relevant academic research and scientific papers
Alkylidene Meldrum's Acids as Platforms for the Vinylogous Synthesis of Dihydropyranones
Wittmann, Stéphane,Martzel, Thomas,Pham Truong, Cong Thanh,Toffano, Martial,Oudeyer, Sylvain,Guillot, Régis,Bournaud, Chloée,Gandon, Vincent,Brière, Jean-Fran?ois,Vo-Thanh, Giang
supporting information, p. 11110 - 11114 (2021/04/09)
Upon Br?nsted base organocatalysis, ketone-derived alkylidene Meldrum's acids proved to be competent vinylogous platforms able to undergo a formal (4+2) cycloaddition reaction with dihydro-2,3-furandione, providing an unprecedented route to 3,6-dihydropyran-2-ones as spiro[4.5]decane derivatives with up to 98 % ee thanks to the commercially available Takemoto catalyst. Preliminary investigation showed that this reaction could be extended to other activated ketones, establishing these alkylidene Meldrum's acids as a novel C4-synthon in the vinylogous series.
Enantioselective copper-catalyzed conjugate addition of dimethylzinc to 5-(1-arylalkylidene) Meldrum's acids
Wilsily, Ashraf,Lou, Tiantong,Fillion, Eric
experimental part, p. 2066 - 2072 (2009/12/27)
The asymmetric formation of all-carbon quaternary benzylic stereocenters containing a methyl substituent was realized by the enantioselective copper-catalyzed 1,4-addition of dimethylzinc to alkylidene Meldrum's acids in the presence of a chiral phosphora
Asymmetric synthesis of all-carbon benzylic quaternary stereocenters via conjugate addition to alkylidene and indenylidene Meldrum's acids
Wilsily, Ashraf,Fillion, Eric
supporting information; experimental part, p. 8583 - 8594 (2009/12/28)
(Chemical Equation Presented) A systematic study outlining the enantioselective 1,4-addition of dialkylzinc reagents to 5-(1-arylalkylidene) and indenylidene Meldrum's acids is presented. Variation of the aryl and alkyl groups present on the alkylidene wa
