132488-55-2

Basic information

• Product Name: (2R,11aS)-2-hydroxy-8-(benzyloxy)-1,2,3,10,11,11a-hexahydro-7-methoxy-5H-pyrrolo<2,1-c><1,4>benzodiazepine-5,11-dione
• Synonyms: (2R,11aS)-2-hydroxy-8-(benzyloxy)-1,2,3,10,11,11a-hexahydro-7-methoxy-5H-pyrrolo<2,1-c><1,4>benzodiazepine-5,11-dione
• CAS NO: 132488-55-2
• Molecular Weight: 368.389
• Mol File: 132488-55-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (2R,11aS)-2-hydroxy-8-(benzyloxy)-1,2,3,10,11,11a-hexahydro-7-methoxy-5H-pyrrolo<2,1-c><1,4>benzodiazepine-5,11-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,11aS)-2-hydroxy-8-(benzyloxy)-1,2,3,10,11,11a-hexahydro-7-methoxy-5H-pyrrolo<2,1-c><1,4>benzodiazepine-5,11-dione(132488-55-2)
• EPA Substance Registry System: (2R,11aS)-2-hydroxy-8-(benzyloxy)-1,2,3,10,11,11a-hexahydro-7-methoxy-5H-pyrrolo<2,1-c><1,4>benzodiazepine-5,11-dione(132488-55-2)

Safety Data

• Hazardous Substances Data: 132488-55-2(Hazardous Substances Data)

Upstream product

• 51-35-4 4R-4-hydroxyproline 
• 253777-45-6 7-benzyloxy-6-methoxyisatoic anhydride 
• 706816-84-4 (2S,4R)-1-(2-Azido-4-benzyloxy-5-methoxy-benzoyl)-4-hydroxy-pyrrolidine-2-carboxylic acid methyl ester 
• 382137-65-7 methyl-(2S,4R)-N-[4-benzyloxy-5-methoxy-2-nitrobenzoyl]-4-hydroxypyrrolidine-2-carboxylate 
• 126588-03-2 N-<5-methoxy-4-(benzyloxy)-2-nitrobenzoyl>hydroxyproline ethyl ester 
• 64154-80-9 (2S,4R)-1-(4-Benzyloxy-5-methoxy-2-nitro-benzoyl)-4-hydroxy-pyrrolidine-2-carboxylic acid 

Relevant articles and documents

Efficient reduction of aromatic nitro/azido groups on solid support employing indium: Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones

An efficient method for the reduction of aromatic nitro and azido compounds on solid support using indium/NH4Cl is described. This solid-phase reduction technique has been applied to the synthesis of pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

One-pot microwave-assisted selective azido reduction/tandem cyclization in condensed and solid phase with nickel boride

An efficient and inexpensive method using microwave-assisted irradiation with Ni2B for the syntheses of aromatic amines, pyrrolobenzodiazepines as well as pyrroloquinazolinones was developed. This protocol was applied in the tandem resin-cleavage, azido reduction, and cyclization of compounds 3 and 5 that afforded substituted pyrrolo[2,1-c][1,4] benzodiazepines 4 and 6 in a one-pot manner. The microwave-assisted irradiation reactions enhanced yields with very short reaction times in contrast to the conventional thermal reactions. Georg Thieme Verlag Stuttgart.

Facile and efficient solid-phase synthesis of DNA-interactive pyrrolo[2,1-c] [1,4]benzodiazepines

The solid-phase synthesis of pyrrolo[2,1-c][1,4]benzodiazepines is described. Isatoic anhydrides attached to chloromethyl Wang resin are coupled with proline and the polymer-bound tricyclic compounds are reduced using very mild conditions, and successivel