132509-67-2

Upstream product

• 16954-69-1 2-methylaminobenzthiazole 
• 16361-69-6 1-(4-nitrophenyl)-3-methyl-thiourea 
• 2131-61-5 p-nitrophenyl isothiocyanate 
• 2407-11-6 2-chloro-6-nitrobenzothiazole 
• 74-89-5 methylamine 
• 115581-72-1 5-(p-nitroanilino)thiatriazole 
• 100-01-6 4-nitro-aniline 
• 132509-66-1 4-methyl-5-(p-nitrophenyl)imino-1,2,3,4-thiatriazoline 

Relevant academic research and scientific papers

A facile synthesis of 2-N(methyl amino) benzothiazoles

Reaction of aromatic primary amines with methylisothiocyanate (MITC) yielded N-methyl-N1-(benzelene-1-yl)thioureas which underwent oxidative cyclization in the presence of bromine in acetic acid, at room temperature, affording the title compounds.

NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF

The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.

Novel hydrazone derivatives comprising aryl or heteroaryl group substituted at terminal amine and use thereof

The present invention relates to novel hydrazone derivatives with an aryl or heteroaryl group substituted at a terminal amine group thereof and a use thereof.

NOVEL MCH RECEPTOR ANTAGONISTS

The present invention relates to a melanin concentrating hormone antagonist compound of formula (I); wherein Ar1, L1, R1, q, X, R2, R3, R4, and R5 are as defined, or a pharmaceutically acceptable salt, solvate, or enantiomer thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.

Synthesis and Reactivity of 1,2,4-Oxathiazolidin-3-imines

Thiatriazolin 4a decomposes in acetone and yields a thermolabile crystalline material, identified as the 1,2,4-oxathiazole derivative 6a on the basis of ir, 1H and 13C nmr spectroscopy.It degrades to 7a in the crystalline state as well in solution.Cycloaddition-eliminiation reactions of 6a with isothiocyanates proceed rapidly and furnish the same products as previously obtained from 4a.Some other reactions of 4 with carbonyl compounds were briefly investigated and provide evidence for the formation of unstable 1,2,4-oxathiazolidines.