1325207-38-2Relevant academic research and scientific papers
Synthesis of new tetracyclic 7-oxo-pyrido[3,2,1-de]acridine derivatives
Chen, Ching-Huang,Lin, Yi-Wen,Kakadiya, Rajesh,Kumar, Amit,Chen, Yu-Ting,Lee, Te-Chang,Su, Tsann-Long
, p. 5883 - 5893 (2011)
A series of (±)3-hydroxyl- and 2,3-dihydroxy-2,3-dihydro-7- oxopyrido[3,2,1-de]acridines were synthesized for antitumor evaluation. These agents can be considered as analogues of glyfoline or (±)1,2- dihydroxyacronycine derivatives. The key intermediates,
COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR PROTEIN
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, (2022/05/02)
Bifunctional compounds, which find utility as modulators of androgen receptor (AR), are described herein. In particular, the bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds AR, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
