Synthesis of new tetracyclic 7-oxo-pyrido[3,2,1-de]acridine derivatives

Article abstract of DOI:10.1016/j.tet.2011.06.062

A series of (±)3-hydroxyl- and 2,3-dihydroxy-2,3-dihydro-7- oxopyrido[3,2,1-de]acridines were synthesized for antitumor evaluation. These agents can be considered as analogues of glyfoline or (±)1,2- dihydroxyacronycine derivatives. The key intermediates,