132521-66-5

Basic information

• Product Name: 2,4-DICHLORO-3-NITRO-QUINOLINE
• Synonyms: AURORA KA-4144;2,4-DICHLORO-3-NITRO-QUINOLINE;3-NITRO-2,4-DICHLORO QUINOLINE;Zinc02551827;2,4-Dichlor-3-nitro-chinolin
• CAS NO: 132521-66-5
• Molecular Formula: C₉H₄Cl₂N₂O₂
• Molecular Weight: 243.05
• Mol File: 132521-66-5.mol
• Article Data: 33

Chemical Properties

• Melting Point: 102 °C(Solv: methanol (67-56-1); ethyl acetate (141-78-6))
• Boiling Point: 359.7°C at 760 mmHg
• Flash Point: 171.3°C
• Appearance: /
• Density: 1.593g/cm³
• Vapor Pressure: 4.84E-05mmHg at 25°C
• Refractive Index: 1.693
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: -4.98±0.50(Predicted)
• CAS DataBase Reference: 2,4-DICHLORO-3-NITRO-QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLORO-3-NITRO-QUINOLINE(132521-66-5)
• EPA Substance Registry System: 2,4-DICHLORO-3-NITRO-QUINOLINE(132521-66-5)

Safety Data

• Hazardous Substances Data: 132521-66-5(Hazardous Substances Data)

Usage

Uses

2,4-Dichloro-3-nitroquinoline has antitumor activity.

InChI:InChI=1/C9H4Cl2N2O2/c10-7-5-3-1-2-4-6(5)12-9(11)8(7)13(14)15/h1-4H

Upstream product

• 70254-44-3 2,4-dihydroxyquinoline 
• 15151-57-2 2,4-dihydroxy-3-nitroquinoline 
• 10025-87-3 trichlorophosphate 
• 15151-57-2 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-one 

Downstream Products

• 580-17-6 3-aminoquinoline 
• 133860-75-0 2-chloro-N⁴-(2-methylpropyl)-3-nitroquinoline-4-amine 
• 259180-86-4 2-chloro-3-nitro-4-[2-(N-triphenylmethyl-4-piperidyl)ethylamino]quinoline 
• 132521-67-6 2-chloro-3-nitroquinolin-4-amine 
• 936544-93-3 tert-butyl 3-{[(3-amino-2-chloroquinolin-4-yl)amino]methyl}benzylcarbamate 
• 1258457-58-7 1-(3-(aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-ylamine 
• 1258457-56-5 C₂₇H₃₃N₅O₂ 
• 144875-48-9 resquimod 
• 1508303-97-6 5-chloro-2-[(1-isobutyl-1H-imidazo[4,5-c]quinolin-4-yl)amino]benzoic acid 
• 1508303-98-7 5-iodo-2-[(1-isobutyl-1H-imidazo[4,5-c]quinolin-4-yl)amino]benzoic acid 
• 1508303-93-2 2-[(1-isobutyl-1H-imidazo[4,5-c]quinolin-4-yl)amino]benzoic acid 
• 1508303-94-3 3-bromo-2-[(1-isobutyl-1H-imidazo[4,5-c]quinolin-4-yl)amino]benzoic acid 
• 1508303-95-4 5-bromo-2-[(1-isobutyl-1H-imidazo[4,5-c]quinolin-4-yl)amino]benzoic acid 
• 1508303-96-5 4-chloro-2-[(1-isobutyl-1H-imidazo[4,5-c]quinolin-4-yl)amino]benzoic acid 

Relevant articles and documents

IMIDAZOQUINOLINE-TYPE COMPOUNDS AND USES THEREOF

Provided in the present disclosure are imidazoquinoline-type compounds, methods for their preparation, pharmaceutical compositions thereof and their use, wherein the imidazoquinoline-type compounds, upon local administration, form depots inducing cell mediated immune response while mitigating a systemic proinflammatory immune response.

SUBSTITUTED QUINOLINONYL PIPERAZINE COMPOUNDS USEFUL AS T CELL ACTIVATORS

Disclosed are compounds of Formula (I) or a salt thereof, wherein: R1, R2, R3, R4, R5, R6, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activi

TLR7/8 AGONISTS AND LIPOSOME COMPOSITIONS

The present disclosure relates to a method of loading a toll like receptor (TLR)7/8 agonist into a liposome using remote loading and a kit of parts suitable for the loading of a TLR7/8 agonist into a liposome by said method. The present disclosure further relates to a liposome comprising a salt of a TLR7/8 agonist in the liposome interior and to the use of said liposome for stimulation of an immune response and/or treatment of a clinical condition. Finally, the present disclosure relates to a TLR7/8 agonist which is suitable for being remotely loaded into a liposome.