1252018-28-2

Usage

Uses

Used in Pharmaceutical Industry:
(R)-4-(4-(5-(chloroMethyl)-2-oxooxazolidin-3-yl)phenyl)Morpholin-3-one is used as an anti-cancer agent for its ability to induce tumor cell death and inhibit tumor growth. It activates the tumor suppressor gene TRAIL, leading to a cascade of events that result in cancer cell death.
Used in Cancer Research:
(R)-4-(4-(5-(chloroMethyl)-2-oxooxazolidin-3-yl)phenyl)Morpholin-3-one is used as a research compound to study its potential applications in cancer therapy and to understand its mechanism of action. Further research and clinical studies are needed to fully comprehend its effectiveness and safety profile in treating various types of cancer.
Used in Drug Development:
(R)-4-(4-(5-(chloroMethyl)-2-oxooxazolidin-3-yl)phenyl)Morpholin-3-one is used as a lead compound in the development of new cancer therapeutics. Its low toxicity in normal cells and potential to activate the tumor suppressor gene TRAIL make it a promising candidate for the development of targeted cancer treatments.

Upstream product

• 51594-55-9 (R)-(-)-epichlorohydrin 
• 1325210-64-7 4-(4-isocyanatophenyl)morpholin-3-one 
• 29518-11-4 4-phenylmorpholin-3-one 
• 122-98-5 2-Anilinoethanol 
• 438056-69-0 4-(4-aminophenyl)morpholin-3-one 
• 446292-04-2 4-(4-nitrophenyl)-3-morpholinone 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 1252018-10-2 4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)amino)phenyl]morpholin-3-one 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 446292-10-0 4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one 
• 366789-02-8 Rivaroxaban 
• 1349248-79-8 4-{4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one 
• 446292-08-6 2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione 
• 1424942-78-8 4-{4-[(5S)-5-(N-benzylaminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morphoIin-3-one 
• 1411775-01-3 4-{4-[(5S)-aminomethyI-2-oxo-1,3-oxazolidine-3-yl]-phenyl}-morphoIine-3-one acetate 
• 1372665-04-7 4-{4-[(5S)-5-((dibenzylamino)methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one 
• 1252018-26-0 4-[4-((R)-5-(iodomethyl)-2-oxo-oxazolidin-3-yl)phenyl]-morpholin-3-one 
• 898543-06-1 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one hydrochloride 

Relevant academic research and scientific papers

An approach to the anticoagulant agent rivaroxaban via an isocyanate-oxirane cycloaddition promoted by MgI2.etherate

A convergent and efficient synthesis of anticoagulant rivaroxaban was developed using the cycloaddition of commercially available (R)-epichlorohydrin with 4-(morpholin-3-one)phenyl isocyanate catalysed by MgI2 etherate as the key step, in 22% overall yield.

PROCESSES FOR THE PREPARATION OF 4-{4-[5(S)-(AMINOMETHYL)-2-OXO-1,3-OXAZOLIDIN-3-YL]PHENYL} MORPHOLIN-3-ONE

The present invention provides processes for the preparation of 4-{4-[5(S)-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one which are simple, eco-friendly, cost-effective, reproducible, robust and are well amenable on industrial scale.

METHOD FOR THE PREPARATION OF SUBSTITUTED OXAZOLIDINONES

The present invention relates to methods for the preparation of a compound having the formula (X). Individual reaction steps as welt as intermediates are additionally claimed.

PROCESS FOR THE PREPARATION OF A RIVAROXABAN AND INTERMEDIATES FORMED IN SAID PROCESS

The invention relates to a process for the preparation of 5-chloro- N- ({(5-S)-2-oxo3-[4-(3-oxo-morj)holine-4-yl)-phenyl]-l,3-oxazolidine-5-yl}-methyl) thiophen-2-carboxamide having the INN rivaroxaban. The process is characterized by the reactions according to claim 1. The invention also relates to intermediates formed in the above process.