132541-52-7

Basic information

• Product Name: Hydroxy(2-naphthyl)Methanephosphonic Acid
• Synonyms: Hydroxy(2-naphthyl)Methanephosphonic Acid;P-(Hydroxy-2-naphthalenylMethyl)phosphonic Acid
• CAS NO: 132541-52-7
• Molecular Formula: C11H11O4P
• Molecular Weight: 238
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Tyrosine Kinase Inhibitors;Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Tyrosine Kinase Inhibitors
• Mol File: 132541-52-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 527.2°Cat760mmHg
• Flash Point: 272.6°C
• Appearance: /
• Density: 1.514g/cm³
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO, Methanol
• CAS DataBase Reference: Hydroxy(2-naphthyl)Methanephosphonic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: Hydroxy(2-naphthyl)Methanephosphonic Acid(132541-52-7)
• EPA Substance Registry System: Hydroxy(2-naphthyl)Methanephosphonic Acid(132541-52-7)

Safety Data

• Hazardous Substances Data: 132541-52-7(Hazardous Substances Data)

Usage

Description

HNMPA is a cell impermeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity. It does not affect protein kinase C or cyclic AMP-dependent protein kinase activities. HNMPA inhibits the insulin-stimulated autophosphorylation of the 95-kDa β-subunit of the insulin receptor with an IC50 value of 200 μM in vitro.

Uses

Different sources of media describe the Uses of 132541-52-7 differently. You can refer to the following data:
1. Insulin receptor tyrosine kinase (IRTK) inhibitor.
2. A selective insulin receptor tyrosine kinase inhibitor

references

[1]. baltensperger k, lewis re, woon cw, et al. catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. proc natl acad sci u s a. 1992 sep 1;89(17):7885-9.[2]. moon mj, kim hy, park s, et al. insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1. mol cells. 2011 oct;32(4):389-95.

Upstream product

• 1090-99-9 diethyl α-hydroxy(2-naphthylmethyl)-phosphonate 
• 66-99-9 β-naphthaldehyde 
• 132541-51-6 bis(2,2-dimethylethyl) (2-naphthalenylhydroxymethyl)phosphonate 

Relevant articles and documents

Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein

Various small fragments bearing phosphate, phosphonate or phosphonic acid moieties have been prepared through parallel synthesis and their binding potencies evaluated on the Src SH2 protein using a BIAcore assay. This provided us insight into the requirement of the Src SH2 pTyr binding pocket and some promising small ligands have been characterised.

Phosphonate-containing inhibitors of tyrosine-specific protein kinases

Tyrosine-specific protein kinases (TPK) are important signal transducing enzymes involved in normal cellular growth and differentiation and have been implicated in the etiology of a number of human neoplastic processes. Efforts to develop agents which inh