13255-50-0

Usage

Uses

Used in Pharmaceutical Industry:
4-CARBOXALDEHYDE-N-ISOPROPYLBENZAMIDE is used as a metabolite in the pharmaceutical industry for its potential role in the development of anti-neoplastic agents. Its formation from the oxidation of an anti-neoplastic agent suggests that it may play a significant role in the metabolism and efficacy of these drugs, potentially leading to improved cancer treatments.
Used in Research and Development:
In the field of research and development, 4-CARBOXALDEHYDE-N-ISOPROPYLBENZAMIDE serves as a valuable compound for studying the metabolic pathways and mechanisms of action of anti-neoplastic agents. Understanding its properties and interactions with other molecules can contribute to the design and synthesis of more effective cancer therapies.
Used in Drug Metabolism Studies:
4-CARBOXALDEHYDE-N-ISOPROPYLBENZAMIDE is used as a research tool in drug metabolism studies to investigate the biotransformation processes of anti-neoplastic agents. This knowledge can help researchers optimize drug formulations and dosing regimens, ultimately enhancing the safety and effectiveness of cancer treatments.

InChI:InChI=1/C11H13NO2/c1-8(2)12-11(14)10-5-3-9(7-13)4-6-10/h3-8H,1-2H3,(H,12,14)

Upstream product

• 671-16-9 Procarbazine 
• 16173-52-7 4-formylbenzoyl chloride 
• 75-31-0 isopropylamine 
• 1122-91-4 4-bromo-benzaldehyde 
• 1642-81-5 p-(chloromethyl)benzoic acid 
• 876-08-4 p-(chloromethyl)benzoyl chloride 
• 104-87-0 4-methyl-benzaldehyde 
• 2144-17-4 N-isopropyl-4-methylbenzamide 
• 99-94-5 p-Toluic acid 
• 874-60-2 4-methyl-benzoyl chloride 

Downstream Products

• 105-07-7 4-cyanobenzaldehyde 
• 671-16-9 Procarbazine 
• 16103-51-8 4-(hydroxymethyl)-N-isopropylbenzamide 

Relevant academic research and scientific papers

Introduction of Z-GP scaffold into procarbazine reduces spermatoxicity and myelosuppression

Incorporation of carbobenzoxy-glycylprolyl (Z-GP) to either α or β position of the hydrazine moiety in procarbazine (Pcb) has been carried on in 5-steps process. The overall yield was 32.7%. The new entity Z-GP-Pcb was confirmed targeting to fibroblast activation protein-α (FAPα). Z-GP-Pcb may be hydrolyzed by either isolated rhFAPα or tumor homogenate. It was shown far less cytotoxicity against NCI-H460 cell line than Pcb. Z-GP-Pcb was displayed the potency to reduce spermatoxcity in H22-bearing mice. The mechanism may be ascribed to the blockade of dehydrogenation by α-glycerolphosphate dehydrogenase. This candidate was further proved equal antitumor activity to Pcb. However, the introduction of Z-GP scaffold decreased myelosuppression. All the evidences support that Z-GP-Pcb is a better antitumor agent than Pcb.

Metal- And additive-free C-H oxygenation of alkylarenes by visible-light photoredox catalysis

A metal- and additive-free methodology for the highly selective, photocatalyzed C-H oxygenation of alkylarenes under air to the corresponding carbonyls is presented. The process is catalyzed by an imide-acridinium that forms an extremely strong photooxidant upon visible light irradiation, which is able to activate inert alkylarenes such as toluene. Hence, this is an easy to perform, sustainable and environmentally friendly oxidation that provides valuable carbonyls from abundant, readily available compounds.

Synthetic method of procarbazide hydrochloride intermediate

The invention discloses a synthetic method of a procarbazide hydrochloride intermediate. The preparation method comprises the following step: in a solvent, in the presence of a hydrolysis agent, carrying out hydrolysis reaction as shown in the specification on a compound as shown in a formula II to obtain a compound as shown in a formula I. The preparation method disclosed by the invention has theadvantages of high yield, high purity and stable process, and is suitable for industrial production.

Amide Synthesis by Nickel/Photoredox-Catalyzed Direct Carbamoylation of (Hetero)Aryl Bromides

Herein, we report a one-electron strategy for catalytic amide synthesis that enables the direct carbamoylation of (hetero)aryl bromides. This radical cross-coupling approach, which is based on the combination of nickel and photoredox catalysis, proceeds at ambient temperature and uses readily available dihydropyridines as precursors of carbamoyl radicals. The method's mild reaction conditions make it tolerant of sensitive-functional-group-containing substrates and allow the installation of an amide scaffold within biologically relevant heterocycles. In addition, we installed amide functionalities bearing electron-poor and sterically hindered amine moieties, which would be difficult to prepare with classical dehydrative condensation methods.

Tf2O-Mediated Intermolecular Coupling of Secondary Amides with Enamines or Ketones: A Versatile and Direct Access to β-Enaminones

Based on the Tf2O-mediated intermolecular reaction of secondary amides with enamines derived from ketones, a novel approach to β-enaminones has been developed. The reaction is widely functional group tolerant and highly chemoselective. In the presence of 4 ? molecular sieves, the method can be extended to the one-pot condensation of secondary amides with ketones for NH β-enaminones synthesis.

Synthetic method of procarbazine

The invention discloses a synthetic method of procarbazine (Pcb). The synthetic method comprises following steps: p-tolualdehyde is taken as an initial raw material, dibromocyanuric acid and isopropylamine are added, reaction is carried out at room temperature so as to obtain p-methyl benzoyl isopropylamine; p-methyl benzoyl isopropylamine is dissolved in an organic reagent, N-bromo-succinimide and an initiator are added, heating reflux is carried out, after reaction, the solvent is removed, acetonitrile and a hydrolysis promoter are added, heating reflux is carried out so as to obtain p-formyl benzoyl isopropylamine; p-formyl benzoyl isopropylamine and methylhydrazine sulfate are dissolved in an organic reagent, triethylamine is added for reaction, and the solvent is subjected to rotary drying, sodium cyanoborohydride is added, an obtained reaction system is heated to room temperature, reaction is carried out for more than one night so as to obtain Pcb. According to the synthetic method, bromination is carried out firstly, and then hydrolysis is carried out, p-methyl benzoyl isopropylamine is converted into p-formyl benzoyl isopropylamine, using of strong oxidizing agent and strong acid is avoided, the synthetic method is friendly to the environment, the yield is high, and the total yield of the three steps is 52.9%.

Synthesis process of anti-cancer medicine propiconazole (by machine translation)

The synthesis method has the advantages of reasonable design, simplified synthesis method, high unit reaction yield, mild conditions, reduced energy consumption and resource conservation, thereby effectively 4 - solving the problems and disadvantages in the existing device 136 mg 1.0 mmol 10 ml 3.0 ml 80 °C 3 h. (by machine translation)

CHEMOKINE RECEPTOR BINDING COMPOUNDS

The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR4 or CCR5. In one aspect, these compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).