132560-60-2Relevant academic research and scientific papers
Oxy-sulfonylation of terminal alkynesviaC-S coupling enabled by copper photoredox catalysis
Charpe, Vaibhav Pramod,Das, Deb Kumar,Hwang, Kuo Chu,Hwu, Jih Ru,Lin, Chun-Cheng,Pampana, V. K. K.,Sagadevan, Arunachalam
supporting information, p. 3569 - 3574 (2021/06/06)
We report the first literature example using visible light-induced trimethylsilyl azide (TMS-N3)-assisted copper-catalyzed oxy-sulfonylation of terminal C-C bonds to form β-keto sulfones (C-S bond formation). TMS-N3promotes the reaction by facilitating the formation of sulfonyl radicals, which later decompose into N2gas upon light irradiation. This method involves the use of commercially available and stable starting materials. Also, a wide range of functional groups have been well-tolerated under the current photoredox process, evading the side product formation. Potent biologically active compounds, such as CES1, 11β-HSD1 inhibitors, anti-analgesic agents, and reactive synthesis intermediates were synthesized to demonstrate the synthetic utility of the current methodology. Moreover, green chemistry metrics and Eco-scale evaluation for the current photochemical method show that the protocol is eco-friendly and highly efficient.
Incorporation of molecular nitrogen into organic compounds IV. Novel lactam synthesis by nitrogenation of enol lactones
Uozumi, Yasuhiro,Mori, Eiko,Mori, Miwako,Shibasaki, Masakatsu
, p. 93 - 102 (2007/10/02)
Enol lactones 7, which are readily prepared from o-haloacetophenone derivatives 15 by palladium-catalyzed carbonylation, react with the titanium-isocyanate complex (1) generated by fixation of CO2 with titanium-nitrogen complex to give the isoindolinone derivatives 8 in good yields.
