1325755-24-5

Basic information

• Product Name: C₁₈H₁₄N₄O₂
• CAS NO: 1325755-24-5
• Molecular Weight: 318.335
• Mol File: 1325755-24-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₄N₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₄N₄O₂(1325755-24-5)
• EPA Substance Registry System: C₁₈H₁₄N₄O₂(1325755-24-5)

Safety Data

• Hazardous Substances Data: 1325755-24-5(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 57691-07-3 ethyl [(E)-3-oxo-1,3-dihydroisobenzofuran-1-ylidene]acetate 
• 356790-62-0 ethyl 2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetate 
• 28081-52-9 2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid 
• 873-74-5 4-Aminobenzonitrile 

Relevant articles and documents

Phthalazinone inhibitors of inosine-5′-monophosphate dehydrogenase from Cryptosporidium parvum

Cryptosporidium parvum (Cp) is a potential biowarfare agent and major cause of diarrhea and malnutrition. This protozoan parasite relies on inosine 5′-monophosphate dehydrogenase (IMPDH) for the production of guanine nucleotides. A CpIMPDH-selective N-aryl-3,4-dihydro-3-methyl-4-oxo-1- phthalazineacetamide inhibitor was previously identified in a high throughput screening campaign. Herein we report a structure-activity relationship study for the phthalazinone-based series that resulted in the discovery of benzofuranamide analogs that exhibit low nanomolar inhibition of CpIMPDH. In addition, the antiparasitic activity of select analogs in a Toxoplasma gondii model of C. parvum infection is also presented.