132588-36-4

Basic information

• Product Name: 6-Amino-3-methyl-5-nitroso-1-phenethyl-1H-pyrimidine-2,4-dione
• CAS NO: 132588-36-4
• Molecular Weight: 274.279
• Mol File: 132588-36-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-Amino-3-methyl-5-nitroso-1-phenethyl-1H-pyrimidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Amino-3-methyl-5-nitroso-1-phenethyl-1H-pyrimidine-2,4-dione(132588-36-4)
• EPA Substance Registry System: 6-Amino-3-methyl-5-nitroso-1-phenethyl-1H-pyrimidine-2,4-dione(132588-36-4)

Safety Data

• Hazardous Substances Data: 132588-36-4(Hazardous Substances Data)

Upstream product

• 6953-30-6 1-methyl-3-phenethylurea 
• 54052-72-1 6-amino-3-methyl-1-phenethyl-1H-pyrimidine-2,4-dione 

Downstream Products

• 132560-12-4 8-Ethyl-1-methyl-3-phenethyl-3,7-dihydro-purine-2,6-dione 
• 132560-06-6 1-Methyl-3-phenethyl-3,7-dihydro-purine-2,6-dione 
• 132560-11-3 1,8-Dimethyl-3-phenethyl-3,7-dihydro-purine-2,6-dione 
• 54052-64-1 5,6-diamino-3-methyl-1-phenethyl-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Structure-activity relationships in a series of xanthine derivatives with antibronchoconstrictory and bronchodilatory activities

Thirty-one 1,3,7,8-substituted xanthine derivatives have been synthesized and evaluated for bronchodilator and anti-bronchoconstrictory activities in in vitro tracheal relaxation and in vivo bronchospasm inhibition models. Activity tests have been complemented with phosphodiesterase inhibition and toxicological data. Structure-activity relationships are discussed. Compound 21 (1,3-diisobutyl-8-methylxanthine) has been selected for further pharmacological development because of its good activity profile and favourable therapeutic index, which is 14- and 38-fold greater than that of theophylline and IBMX, respectively.