132560-11-3 Usage
Molecular Structure
Complex, derivative of purine
Functional Groups
Two methyl groups
Phenylethyl group
Dihydro-1H-purine-2,6-dione core
Medical Use
Bronchodilator
Conditions Treated
Asthma
Bronchitis
Emphysema
Mechanism of Action
Relaxes airway muscles, increases lung capacity
Central Nervous System Effects
Stimulant, improves alertness and physical performance
Administration
Medical supervision required
Therapeutic Range
Narrow
Potential Side Effects
Yes, due to narrow therapeutic range
Check Digit Verification of cas no
The CAS Registry Mumber 132560-11-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,5,6 and 0 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 132560-11:
(8*1)+(7*3)+(6*2)+(5*5)+(4*6)+(3*0)+(2*1)+(1*1)=93
93 % 10 = 3
So 132560-11-3 is a valid CAS Registry Number.
132560-11-3Relevant academic research and scientific papers
Structure-activity relationships in a series of xanthine derivatives with antibronchoconstrictory and bronchodilatory activities
Merlos,Gomez,Vericat,Bartroli,Garcia-Rafanell,Forn
, p. 653 - 658 (2007/10/02)
Thirty-one 1,3,7,8-substituted xanthine derivatives have been synthesized and evaluated for bronchodilator and anti-bronchoconstrictory activities in in vitro tracheal relaxation and in vivo bronchospasm inhibition models. Activity tests have been complemented with phosphodiesterase inhibition and toxicological data. Structure-activity relationships are discussed. Compound 21 (1,3-diisobutyl-8-methylxanthine) has been selected for further pharmacological development because of its good activity profile and favourable therapeutic index, which is 14- and 38-fold greater than that of theophylline and IBMX, respectively.
