132608-46-9Relevant academic research and scientific papers
Thiourea catalysed reduction of α-keto substituted acrylate compounds using Hantzsch ester as a reducing agent in water
Weng, Guanglin,Ma, Xiaobo,Fang, Dongmei,Tan, Ping,Wang, Lijiao,Yang, Linlin,Zhang, Yuanyuan,Qian, Shan,Wang, Zhouyu
, p. 22909 - 22912 (2017)
The first method for the reduction of α-keto substituted acrylate compounds by Hantzsch ester in water under the catalysis of thiourea has been developed. The products were isolated in moderate to high yields (38-95%). These products are important intermediates in the synthesis of a series of natural products and other biologically active molecules.
Method for preparing alpha-alkyl-beta-ketone ester compound
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Paragraph 0094-0097, (2018/05/01)
The invention discloses a method for preparing an alpha-alkyl-beta-ketone ester compound shown as a formula (I). The method comprises the following steps: a 1,4-dihydropyridine ester compound shown asa formua (III) is taken as a reducing agent, and under existence of a Lewis acid catalyst, a compound in a formula (II) is subjected to a reduction reaction to obtain the alpha-alkyl-beta-ketone ester compound shown as the formula (I). The method has the advantages of simple operation, mild condition and environmental protection, and is suitable for a plurality of substrates, and the yield can reach as highest as 95%. By using the method of the invention, a plurality of alpha-alkyl-beta-ketone ester compounds can be efficiently prepared, types of medical intermediates are enriched, and the method has an excellent industrial application prospect.
REACTIONS OF 2-METHYLENE-1,3-DICARBONYL COMPOUNDS WITH FURAN
Yamauchi, Masashige,Shirota, Miwa,Watanabe, Toshio
, p. 1699 - 1704 (2007/10/02)
The mono- and/or di-substituted furans (2 and 3) were synthesized by the reaction of 2-methylene-1,3-dicarbonyl compounds (1) with furan under moderate selectivity.
