1326231-91-7Relevant academic research and scientific papers
ENZYME-SPECIFIC FLUORESCENT COMPOUND CAPABLE OF BEING RETAINED IN CELLS
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Paragraph 0090; 0091; 0092, (2017/04/19)
Provided is an enzyme-specific fluorescent compound capable of being retained in cells, which can emit fluorescence specifically in a target cell, particularly a cell capable of expressing a reporter enzyme such as β-galactosidase, and can covalently bind to a protein in the cell to exhibit an excellent property of being retained in the cell. The fluorescent compound comprises a compound represented by formula (I′) or a salt thereof. In formula (I′), A, X, Y and R1 to R9 are as described in claim 1.
β-galactosidase fluorescence probe with improved cellular accumulation based on a spirocyclized rhodol scaffold
Kamiya, Mako,Asanuma, Daisuke,Kuranaga, Erina,Takeishi, Asuka,Sakabe, Masayo,Miura, Masayuki,Nagano, Tetsuo,Urano, Yasuteru
supporting information; experimental part, p. 12960 - 12963 (2011/10/05)
We identified a rhodol bearing a hydroxymethyl group (HMDER) as a suitable scaffold for designing fluorescence probes for various hydrolases. HMDER shows strong fluorescence at physiological pH, but phenolic O-alkylation of HMDER results in a strong prefe
