1326236-33-2

Upstream product

• 81228-09-3 2,4-difluorophenylacetic acid 
• 876372-85-9 2-(2,4-difluorophenyl)-N-methoxy-N-methylacetamide 
• 1449112-25-7 3-(2,4-difluorophenyl)-1-methoxy-1-(phenylthio)propan-2-one 
• 1449112-23-5 C₁₂H₁₂F₂OS₂ 
• 1449112-24-6 C₁₁H₁₂F₂OS₂ 
• 1449112-26-8 3-(2,4-difluorophenyl)-1,1-dimethoxypropan-2-one 
• 37156-84-6 4-(5-amino-6-benzyl-pyrazin-2-yl)-phenol 
• 1449112-30-4 C₁₁H₁₀F₂O₃ 

Downstream Products

• 1326236-35-4 (Z)-8-benzyl-2-(2,4-difluorobenzylidene)-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazine-3(2H)-one 

Relevant academic research and scientific papers

Chemical synthesis of coelenterazine and its analogs: New route by four segment-couplings

A novel and improved synthetic route includes four segment-couplings toward coelenterazine and its analogs as luminescent molecules. Regio- and chemo-selective cross coupling reactions using palladium catalysts with 5-iodo-3-bromo-2-aminopyrazine have enabled providing various aminopyrazine derivatives having different substituents. The improved synthesis of coelenterazine and its analogs employed advanced condensation with the aminopyrazines using various keto-acetal segments, which resulted in much higher yields to give the final imidazopyrazinone heterocycles than the previous method using keto-aldehydes.

Dynamic chirality determines critical roles for bioluminescence in symplectin-dehydrocoelenterazine system

Symplectin is a photoprotein containing the dehydrocoelenterazine (DCL) chromophore, which links to a cysteine residue through a covalent bond with the emission of blue light. This study focuses on the stereochemical process of the emerging stereogenic ce