802918-29-2

Upstream product

• 1326308-17-1 3,5,7,20-O-tetra-acetyl-23-O-(4,4'-dimethoxytriphenylmethyl)-silybin 
• 1326308-16-0 23-O-(4,4’-dimethoxytriphenylmethyl)silibinin 
• 802918-28-1 2-(2-{[(tert-butyldimethylsilyl)oxy]methyl}-3-(4-hydroxy-3-methoxyphenyl)-2,3-dihydro-1,4-benzodioxin-6-yl)-3,5,7-trihydroxychroman-4-one 
• 802918-57-6 silybin 

Downstream Products

• 802918-32-7 3-(4-acetoxy-3-methoxyphenyl)-6-[3,5,7-triacetoxy-4-oxochroman-2-yl]-2,3-dihydro-1,4-benzodioxine-2-carboxylic acid 
• 1326308-20-6 (3,5,7,20-O-tetra-acetyl)-silybin-23-O-(4-nitrophenyl)-phosphate 
• 1326308-09-1 3,5,7,20-O-tetra-acetyl-23-O-methansulfonyl-silybin 
• 1326308-18-2 3,5,7,20-O-tetra-acetyl-23-O-sulphate silybin 
• 1326308-05-7 sodium silybin-23-O-sulphate 
• 1326344-95-9 C₂₅H₂₂O₁₃S 
• 1326308-21-7 C₃₁H₂₆NO₁₅P 
• 1326308-06-8 23-azide-silybin 
• 1326308-07-9 23-amine-silybin 
• 1326308-08-0 sodium silybin-23-O-(4-nitrophenyl)-phosphate 

Relevant academic research and scientific papers

New silybin scaffold for chemical diversification: Synthesis of novel 23-phosphodiester silybin conjugates

Silybin is the major component (ca. 30%) of the silymarin complex extracted from the seeds of Silybum marianum, with multiple biological activities operating at various cell levels. As an ongoing effort toward the exploitation of natural products as scaffolds for chemical diversification at readily accessible positions, we present here an efficient synthetic procedure to obtain new 23-phosphodiester silybin conjugates with different labels. A key point in our approach is the new 3,5,7,20-tetra-O-acetylsilybin-23-phosphoramidite, useful for a variety of derivatizations following a reliable and well-known chemistry. The feasibility of the procedure has been demonstrated by preparing new 23-silybin conjugates, exploiting standard phosphoramidite chemistry. Georg Thieme Verlag Stuttgart · New York.

New C-23 modified of silybin and 2,3-dehydrosilybin: Synthesis and preliminary evaluation of antioxidant properties

Silybin is the major flavonolignan of silymarin and it displays a plethora of biological effects, generally ascribed to its antioxidant properties. Herein we shall describe an efficient synthetic strategy to obtain a variety of new and more water-soluble

Oxidised derivatives of silybin and their antiradical and antioxidant activity

Carboxylic acids derived from silybin (1) and 2,3-dehydrosilybin (2) with improved water solubility were prepared by selective oxidation of parent compounds and a new inexpensive method for preparation of 2,3-dehydrosilybin from silybin was developed and