191980-54-8

Upstream product

• 3469-69-0 4-iodopyrazole 
• 76-83-5 trityl chloride 

Downstream Products

• 398152-64-2 N-{3-[3-fluoro-4-(1-trityl-1H-pyrazol-4-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 
• 466671-49-8 4-[hydroxy-(1-trityl-1H-pyrazol-4-yl)-methyl]-benzonitrile 
• 466671-50-1 (4-aminomethyl-phenyl)-(1-trityl-1H-pyrazol-4-yl)-methanol 
• 466671-51-2 1-(3,5-dichloro-phenyl)-3-{4-[hydroxy-(1-trityl-1H-pyrazol-4-yl)-methyl]-benzyl}-urea 
• 936484-37-6 4-ferrocenyl-1-tritylpyrazole 
• 1269071-49-9 S-(1-tritylpyrazol-4-yl) benzenecarbothioate 
• 1269071-57-9 1-tritylpyrazole-4-sulfonyl chloride 
• 1310452-63-1 4-[1-(pyridin-2-yl)vinyl]-1-trityl-1H-pyrazole 
• 1310452-60-8 4-(2-phenylvinyl)-1-trityl-1H-pyrazole 
• 1310452-54-0 C₂₉H₂₇N₃O₂ 
• 1310452-55-1 1-trityl-4-vinyl-1H-pyrazole 
• 1310452-62-0 4-[2-(4-nitrophenyl)vinyl]-1-trityl-1H-pyrazole 
• 1310452-61-9 4-[2-(4-fluorophenyl)vinyl]-1-trityl-1H-pyrazole 
• 1310452-51-7 4-(2-tert-butoxycarbonylvinyl)-1-trityl-1H-pyrazole 

Relevant academic research and scientific papers

Tailor-Made Pyrazolide-Based Metal-Organic Frameworks for Selective Catalysis

The predesignable porous structures in metal-organic frameworks (MOFs) render them quite attractive as a host-guest platform to address a variety of important issues at the frontiers of science. In this work, a perfluorophenylene functionalized metalloporphyrinic MOF, namely, PCN-624, has been rationally designed, synthesized, and structurally characterized. PCN-624 is constructed by 12-connected [Ni8(OH)4(H2O)2Pz12] (Pz = pyrazolide) nodes and fluorinated 5,10,15,20-tetrakis(2,3,5,6-tetrafluoro-4-(1H-pyrazol-4-yl)phenyl)-porphyrin (TTFPPP) linker with an ftw-a topological net. Notably, PCN-624 exhibits extinguished robustness under different conditions, including organic solvents, strong acid, and base aqueous solutions. The pore surface of PCN-624 is decorated with pendant perfluorophenylene groups. These moieties fabricate densely fluorinated nanocages resulting in the selective guest capture of the material. More importantly, PCN-624 can be employed as an efficient heterogeneous catalyst for the selective synthesis of fullerene-anthracene bisadduct. Owing to the high chemical robustness of PCN-624, it can be recycled over five times without significant loss of its catalytic activity. All of these results demonstrate that MOFs can serve as a powerful platform with great flexibility for functional design to solve various synthetic problems.

ARYLMETHYLENE HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS

A compound of Formula (I) or a pharmaceutically acceptable salt thereof is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same and method of using the same are also described.

Solvation-dependent switching of solid-state luminescence of a fluorinated aromatic tetrapyrazole

Creating stimuli-responsive materials with switchable solid-state luminescence remains a challenge. We report that the solvation of a novel organic fluorophore can be utilized to prepare such a material, which emits in the blue (442-446 nm) region when we

SUBSTITUTES SULFONYL AZACYCLES AS MODULATORS OF HEDGEHOG (HH) SIGNALLING PATHWAY

There are described compounds of formula (I) in which X, R1, R2 and n are each as herein defined; and their use as a medicament in the treatment of conditions involving abnormal activation and/or malfunction of the hedgehog pathway,

Indolone derivative as well as preparation method and application thereof

The invention relates to a compound represented by formula (A) or a pharmaceutically acceptable salt, a stereoisomer, a tautomer, a polymorphic substance, a solvate, a metabolite or a prodrug thereof,and also relates to a pharmaceutical composition containing the compound. The compound can be used for treating cancer or immune system diseases.

THERMALLY ROBUST, HIGHLY POROUS, AND PARTIALLY FLUORINATED ORGANIC FRAMEWORK WITH AFFINITY FOR HYDROCARBONS, FLUOROCARBONS AND FREONS

Porous partially fluorinated materials which bind aliphatic and aromatic hydrocarbons, fluorocarbons and freons with high weight adsorption capacities are provided. Such compounds may be used in separation of materials by exclusion such as selective separ

Synthesis, SAR and selectivity of 2-acyl- and 2-cyano-1-hetarylalkyl- guanidines at the four histamine receptor subtypes: A bioisosteric approach

In the search for potential bioisosteres of the 4-imidazolyl ring in acylguanidines (e.g. UR-AK24), known to possess affinity to several histamine receptor subtypes (HxR, x = 1-4), and cyanoguanidine-type H 4R agonists (e.g. UR-PI376

HIV protease inhibitors

The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.

Carbon-carbon-linked (pyrazolylphenyl)oxazolidinones with antibacterial activity against multiple drug resistant gram-positive and fastidious gram-negative bacteria.

In an effort to expand the spectrum of activity of the oxazolidinone class of antibacterial agents to include Gram-negative bacteria, a series of new carbon-carbon linked pyrazolylphenyl analogues has been prepared. The alpha-N-substituted methyl pyrazole

Palladium(0)-catalyzed preparation of 4-arylpyrazoles

A general method for the palladium(0)-catalyzed preparation of 4- arylpyrazoles 2, by coupling of either 4-halopyrazoles 3 with arylstannanes 4 or 4-tributylstannyl-1-tritylpyrazole 5 with aryl iodides 6, is reported. Deprotection of trityl and/or methyl