132636-13-6

Basic information

• Product Name: 1-(3-chloropropoxy)-3-nitrobenzene
• Synonyms: 1-(3-chloropropoxy)-3-nitrobenzene;UKRORGSYN-BB BBV-022721
• CAS NO: 132636-13-6
• Molecular Formula: C₉H₁₀ClNO₃
• Molecular Weight: 215.63
• Mol File: 132636-13-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 349.415 °C at 760 mmHg
• Flash Point: 165.12 °C
• Appearance: /
• Density: 1.271 g/cm³
• CAS DataBase Reference: 1-(3-chloropropoxy)-3-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-chloropropoxy)-3-nitrobenzene(132636-13-6)
• EPA Substance Registry System: 1-(3-chloropropoxy)-3-nitrobenzene(132636-13-6)

Safety Data

• Hazardous Substances Data: 132636-13-6(Hazardous Substances Data)

Usage

Type of compound

Organic compound

Structure

Nitrophenyl ether derivative

Functional groups

Nitro group and chloropropoxy group

Attachment

Attached to a benzene ring

Usage

a. Organic synthesis
b. Starting material for complex organic molecules
c. Intermediate in manufacturing
d. Pharmaceutical production
e. Agrochemical production
f. Dye production

Hazardous nature

Potentially hazardous due to nitro and chloro substituents

Safety precautions

Handle with care in a laboratory setting

Upstream product

• 554-84-7 meta-nitrophenol 
• 109-70-6 1.3-chlorobromopropane 
• 6940-76-7 1-iodo-3-chloro-propane 

Downstream Products

• 925921-04-6 C₁₅H₂₂N₂O₄ 
• 925920-63-4 C₁₃H₁₈N₂O₄ 
• 79668-76-1 3-(3-chloropropoxy)benzenamine 

Relevant articles and documents

COMPOUNDS

A compound of formula (I): compositions and medicaments containing the same as well as processes for the preparation and use of such compounds, compositions and medicaments, particularly in diseases associated with inappropriate Aurora activity.

PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE

Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof aryloxyalkylamines, including pyridyloxylalkylamines and phenoxyalkylamines. Exemplary compounds include dimethyl(2-(3-pyridyloxy)ethylamine, dimethyl(4-(3-pyridyloxy)butyl)amine, 2-(3-pyridyloxy)ethylamine, 4-(3-pyridyloxy)butylamine, methyl(3-(5-methoxy-3-pyridyloxy)propyl)amine, ethyl(3-(3-pyridyloxy)propyl)amine, methyl(2-(3-pyridyloxy)ethyl)amine, methyl(3-(6-methyl(3-pyridyloxy))propyl)amine, (3-(3-methoxyphenoxy)propyl)methylamine, (3-(5-chloro(3-pyridyloxy))-1-methylpropyl)methylamine, dimethyl(3-(3-pyridyloxy)propyl)amine, 3-(3-pyridyloxy)propylamine, methyl(4-(3-pyridyloxy)butyl)amine, 3-(5-chloro-3-pyridyloxy)propyl amine, methyl(3-(5-isopropoxy-3-pyridyloxy)propyl)amine, (3-(5-chloro(3-pyridyloxy))propyl) methylamine, methyl(3-(5-(phenylmethoxy)(3-pyridyloxy))propyl)amine, methyl(3-(2-methyl(3-pyridyloxy))propyl)amine, (methylethyl)(3-(3-pyridyloxy)propyl)amine, benzyl(3-(3-pyridyloxy)propyl)amine, cyclopropyl(3-(3-pyridyloxy)-propyl)amine, methyl(1-methyl-3-(3-pyridyloxy)propyl)amine, methyl(3-(3-nitrophenoxy)propyl)amine, 1-(3-chloropropoxy)-3-nitrobenzene, (3-(3-aminophenoxy)propyl)methylamine,dimethyl (3-(3-(methylamino)-propoxy)phenyl)amine, methyl(3-tricyclo[7.3.1.0]tridec-2-yloxypropyl)amine, (3-benzo[3,4-d]1,3-dioxolan-5-yloxypropyl)methylamine, 3-(4-piperidinyloxy)pyridine and 3-((3S)-3-pyrrolidinyloxy)pyridine.

Selectivity in alkylation of phenols with 1-bromo-3-chloropropane using phase-transfer catalysis

The use of various phase-transfer catalysts in the alkylation of phenol and substituted phenols with 1-bromo-3-chloropropane was investigated. When a quarternary ammonium salt of the general formula R'4N+ X-, where R' = alkyl with a minimum chain length of 4 was used, a mixture of 1-aryloxy-3-chloropropane and 1-aryloxy-3-bromopropane resulted. The effect of counterion, added potassium bromide, and catalysts other than quarternary ammonium salts were assessed for the halopropylation of 2,5-dimethylphenol.