132646-26-5

Basic information

• Product Name: 3-Triphenylmethyl-1,3-oxazolidine-2,4-dione
• Synonyms: 3-Triphenylmethyl-1,3-oxazolidine-2,4-dione
• CAS NO: 132646-26-5
• Molecular Weight: 343.382
• Mol File: 132646-26-5.mol

Chemical Properties

• CAS DataBase Reference: 3-Triphenylmethyl-1,3-oxazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Triphenylmethyl-1,3-oxazolidine-2,4-dione(132646-26-5)
• EPA Substance Registry System: 3-Triphenylmethyl-1,3-oxazolidine-2,4-dione(132646-26-5)

Safety Data

• Hazardous Substances Data: 132646-26-5(Hazardous Substances Data)

Upstream product

• 2346-26-1 2,4-oxazolidinedione 
• 76-83-5 trityl chloride 

Downstream Products

• 132646-29-8 N-(triphenylmethyl)-5-<4-<2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy>benzyl>-2,4-oxazolidinedione 
• 150053-51-3 1,4-bis[4-[(2,4-dioxo-3-trityl-5-oxazolidinylchloromethyl)]phenoxy]benzene 
• 132646-48-1 N-(triphenylmethyl)-5-<4-<2-(2-cyclohexyl-5-methyl-4-oxazolyl)ethoxy>benzyl>-2,4-oxazolidinedione 
• 132646-46-9 3-triphenylmethyl-5-([4-hydroxyphenyl]methyl)oxazolidine-2,4-dione 

Relevant articles and documents

Benzyloxazolidine-2,4-diones as potent hypoglycemic agents

A series of benzyloxazolidine-2,4-diones, containing oxazole-based side chains, were found to lower blood glucose levels in the genetically obese ob/ob mouse. Incorporation of a benzofuran structural element in these compounds provides greatly enhanced in vivo potency. The syntheses and structure-activity relationships for this series are detailed.

INDOLES HAVING ANTI-DIABETIC ACTIVITY

Indoles of Formula (I) having -X-aryl-(CH2)x#191-oxazolidinedione and -X-heteroaryl-(CH2)X-oxazolidinedione substituents on the N atom of the indole ring, where x is 0 or 1, and -X-is a bond or -CH2-, and their thiazolidinedione analogs, are PPAR gamma agonists or partial agonists and are useful in the treatment and control of type II diabetes, including hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

Oxazolidinedione hypoglycemic agents

Compounds of the formulae STR1 where R is cycloalkyl or aryl; R1 is alkyl, X is O or C=O; A is O or S; and B is N or CH are useful as hypoglycemic agents.

Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents

A series of 5-(4-[2-substituted benzoxazolylmethoxy]benzyl)oxa- and thiazolidine-2,4-diones as antidiabetic and cholesterol lowering agents.

Oxazolidinedione hypoglycemic agents

Compounds of the formulae where R is cycloalkyl or aryl; R1 is alkyl, X is O or C=O; A is O or S; and B is N or CH are useful as hypoglycemic agents.