2346-26-1

Basic information

• Product Name: 2,4-OXAZOLIDINEDIONE
• Synonyms: 2,4-OXAZOLIDINEDIONE;2,4-oxazolidenedione;Oxazolidin-2,4-dione;oxazolidine-2,4-dione;NSC 120350;1,3-oxazolidine-2,4-dione
• CAS NO: 2346-26-1
• Molecular Formula: C₃H₃NO₃
• Molecular Weight: 101.06
• Mol File: 2346-26-1.mol
• Article Data: 14

Chemical Properties

• Melting Point: 89-90 °C
• Boiling Point: 173 °C(Press: 11 Torr)
• Appearance: /
• Density: 1.469 g/cm³
• Refractive Index: 1.465
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 6.00±0.50(Predicted)
• CAS DataBase Reference: 2,4-OXAZOLIDINEDIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-OXAZOLIDINEDIONE(2346-26-1)
• EPA Substance Registry System: 2,4-OXAZOLIDINEDIONE(2346-26-1)

Safety Data

• Hazardous Substances Data: 2346-26-1(Hazardous Substances Data)

Usage

General Description

2,4-Oxazolidinedione, also known as 2,4-thiazolidinedione, is a chemical compound with the molecular formula C3H3NO2S. It is a heterocyclic organic compound that is used in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential antidiabetic and anti-inflammatory properties, as well as its ability to inhibit the enzyme dipeptidyl peptidase-4 (DPP-4), which is involved in the regulation of blood sugar levels. Additionally, it has been investigated for its potential as an anticonvulsant and as a treatment for inflammatory bowel disease. 2,4-Oxazolidinedione exhibits a variety of biological activities that make it an interesting and versatile compound for further research and development.

InChI:InChI=1/C3H3NO3/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)

Upstream product

• 2346-24-9 2-thio-2,4-oxazolidinedione 
• 7713-43-1 oxazolidine-2,4-dione 2-[(1-phenyl-ethylidene)-hydrazone] 
• 124-38-9 carbon dioxide 
• 79-07-2 Chloroacetamide 
• 703-56-0 N-phenyl-2-oxazolidinone 
• 7732-18-5 water 
• 7726-95-6 bromine 
• 7647-01-0 hydrogenchloride 
• 17816-85-2 2-amino-4(5H)-oxazolone 
• 17351-61-0 tetraethylammonium bicarbonate 
• 497-25-6 dimethylenecyclourethane 
• 598-42-5 glycolamide 
• 105-58-8 Diethyl carbonate 
• 124-41-4 sodium methylate 

Downstream Products

• 14422-90-3 3-methyl-2,4-oxazolidinedione 
• 23969-18-8 1-Hydroxyacetylsemicarbazid 
• 23968-81-2 4-Hydroxyacetylsemicarbazid 
• 128070-53-1 3-(1-Methyl-5-trimethylsilanyl-pent-4-ynyl)-oxazolidine-2,4-dione 
• 142484-34-2 3-<3-(2,4-dioxooxazolidin-5-yl)-3-phenyloxiranyl>propionic acid methyl ester 
• 128070-54-2 3-(1-Propyl-5-trimethylsilanyl-pent-4-ynyl)-oxazolidine-2,4-dione 
• 131842-40-5 4-(Dimethylamino)-1-(2-hydroxyacetyl)-1,3-diazaspiro<4.4>non-3-en-2-on 
• 131842-39-2 5-(Dimethylamino)-3,4-dihydro-3-(2-hydroxyacetyl)-4-isopropyl-4-methyl-2H-imidazol-2-on 
• 142484-26-2 5-(2-hydroxy-1-methylpropylidene)-2,4-oxazolidinedione 
• 142484-27-3 5-(2-hydroxy-1-methylpropylidene)-2,4-oxazolidinedione 
• 132646-26-5 3-Triphenylmethyl-1,3-oxazolidine-2,4-dione 
• 140421-48-3 3-(4-Bromo-1-methyl-pent-4-enyl)-oxazolidine-2,4-dione 
• 109988-58-1 N-<2-(1-phenylethenyl)-5-hexenyl>oxazolidine-2,4-dione 
• 109988-59-2 N-<2-(1-4'-methoxyphenylethenyl)-5-hexenyl>oxazolidine-2,4-dione 

Relevant articles and documents

Discovery, synthesis, and evaluation of N-substituted amino-2(5H)- oxazolones as novel insecticides activating nicotinic acetylcholine receptors

N-Substituted amino-2(5H)-oxazolones A are a novel class of insecticides acting as nicotinic acetylcholine receptor (nAChR) agonists and show potent activity against hemipteran insect species. Here we report the discovery and preparation of this class of chemistry. Our efforts in SAR elucidation, biological activity evaluation, as well as mode-of-action studies are also presented.

Structure Property Relationships of Carboxylic Acid Isosteres

The replacement of a carboxylic acid with a surrogate structure, or (bio)-isostere, is a classical strategy in medicinal chemistry. The general underlying principle is that by maintaining the features of the carboxylic acid critical for biological activity, but appropriately modifying the physicochemical properties, improved analogs may result. In this context, a systematic assessment of the physicochemical properties of carboxylic acid isosteres would be desirable to enable more informed decisions of potential replacements to be used for analog design. Herein we report the structure-property relationships (SPR) of 35 phenylpropionic acid derivatives, in which the carboxylic acid moiety is replaced with a series of known isosteres. The data set generated provides an assessment of the relative impact on the physicochemical properties that these replacements may have compared to the carboxylic acid analog. As such, this study presents a framework for how to rationally apply isosteric replacements of the carboxylic acid functional group.

Dihydroindolone compounds, a process for their preparation and pharmaceutical compositions containing them

Compounds of formula (I): wherein: m and n represent 1 or 2,A represents a pyrrolyl group,X represents a C(O), S(O) or SO2 group,R1 and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group,R3 and R4, together with the atoms carrying them, form a heterocyclic group,R5 represents a hydrogen atom or an alkyl group,R6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.