2346-26-1

Basic information

• Product Name: 2,4-OXAZOLIDINEDIONE
• Synonyms: 2,4-OXAZOLIDINEDIONE;2,4-oxazolidenedione;Oxazolidin-2,4-dione;oxazolidine-2,4-dione;NSC 120350;1,3-oxazolidine-2,4-dione
• CAS NO: 2346-26-1
• Molecular Formula: C₃H₃NO₃
• Molecular Weight: 101.06
• Mol File: 2346-26-1.mol

Chemical Properties

• Melting Point: 89-90 °C
• Boiling Point: 173 °C(Press: 11 Torr)
• Appearance: /
• Density: 1.469 g/cm³
• Refractive Index: 1.465
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 6.00±0.50(Predicted)
• CAS DataBase Reference: 2,4-OXAZOLIDINEDIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-OXAZOLIDINEDIONE(2346-26-1)
• EPA Substance Registry System: 2,4-OXAZOLIDINEDIONE(2346-26-1)

Safety Data

• Hazardous Substances Data: 2346-26-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Oxazolidinedione is used as a key intermediate in the synthesis of various pharmaceuticals. Its potential antidiabetic properties make it a promising candidate for the development of new drugs to treat diabetes mellitus. It has been studied for its ability to inhibit the enzyme dipeptidyl peptidase-4 (DPP-4), which plays a crucial role in the regulation of blood sugar levels.
2,4-Oxazolidinedione is also used as an anti-inflammatory agent. Its potential to modulate inflammatory pathways and reduce inflammation makes it a valuable compound for the development of new treatments for inflammatory disorders.
Used in Agrochemical Industry:
In the agrochemical industry, 2,4-Oxazolidinedione is used as a building block for the synthesis of various agrochemicals. Its unique chemical structure and properties make it suitable for the development of new pesticides and herbicides.
Used in Anticonvulsant Research:
2,4-Oxazolidinedione has been investigated for its potential as an anticonvulsant agent. Its ability to modulate neuronal excitability and reduce seizure activity makes it a promising candidate for the development of new treatments for epilepsy and other seizure disorders.
Used in Inflammatory Bowel Disease Treatment:
2,4-Oxazolidinedione has also been studied for its potential as a treatment for inflammatory bowel disease (IBD). Its anti-inflammatory properties and ability to modulate immune responses make it a valuable compound for the development of new therapies for IBD, including Crohn's disease and ulcerative colitis.

InChI:InChI=1/C3H3NO3/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)

Upstream product

• 7647-01-0 hydrogenchloride 
• 17816-85-2 2-amino-4(5H)-oxazolone 
• 2346-24-9 2-thio-2,4-oxazolidinedione 
• 7732-18-5 water 
• 7726-95-6 bromine 
• 703-56-0 N-phenyl-2-oxazolidinone 
• 17351-61-0 tetraethylammonium bicarbonate 
• 79-07-2 Chloroacetamide 
• 124-38-9 carbon dioxide 
• 497-25-6 dimethylenecyclourethane 
• 7713-43-1 oxazolidine-2,4-dione 2-[(1-phenyl-ethylidene)-hydrazone] 
• 598-42-5 glycolamide 
• 105-58-8 Diethyl carbonate 
• 124-41-4 sodium methylate 

Downstream Products

• 23969-18-8 1-Hydroxyacetylsemicarbazid 
• 23968-81-2 4-Hydroxyacetylsemicarbazid 
• 128070-53-1 3-(1-Methyl-5-trimethylsilanyl-pent-4-ynyl)-oxazolidine-2,4-dione 
• 142484-34-2 3-<3-(2,4-dioxooxazolidin-5-yl)-3-phenyloxiranyl>propionic acid methyl ester 
• 128070-54-2 3-(1-Propyl-5-trimethylsilanyl-pent-4-ynyl)-oxazolidine-2,4-dione 
• 131842-40-5 4-(Dimethylamino)-1-(2-hydroxyacetyl)-1,3-diazaspiro<4.4>non-3-en-2-on 
• 131842-39-2 5-(Dimethylamino)-3,4-dihydro-3-(2-hydroxyacetyl)-4-isopropyl-4-methyl-2H-imidazol-2-on 
• 142484-26-2 5-(2-hydroxy-1-methylpropylidene)-2,4-oxazolidinedione 
• 142484-27-3 5-(2-hydroxy-1-methylpropylidene)-2,4-oxazolidinedione 
• 132646-26-5 3-Triphenylmethyl-1,3-oxazolidine-2,4-dione 
• 140421-48-3 3-(4-Bromo-1-methyl-pent-4-enyl)-oxazolidine-2,4-dione 
• 109988-58-1 N-<2-(1-phenylethenyl)-5-hexenyl>oxazolidine-2,4-dione 
• 109988-59-2 N-<2-(1-4'-methoxyphenylethenyl)-5-hexenyl>oxazolidine-2,4-dione 
• 131842-38-1 5-(Dimethylamino)-3,4-dihydro-3-(2-hydroxyacetyl)-4,4-dimethyl-2H-imidazol-2-on 

Relevant articles and documents

Discovery, synthesis, and evaluation of N-substituted amino-2(5H)- oxazolones as novel insecticides activating nicotinic acetylcholine receptors

N-Substituted amino-2(5H)-oxazolones A are a novel class of insecticides acting as nicotinic acetylcholine receptor (nAChR) agonists and show potent activity against hemipteran insect species. Here we report the discovery and preparation of this class of chemistry. Our efforts in SAR elucidation, biological activity evaluation, as well as mode-of-action studies are also presented.

MODIFIED COMPOUND OF ANDROGRAPHOLIDE

The present disclosure discloses a modified compound of andrographolide, and particularly discloses a compound shown in formula (I) and (II) or a pharmaceutically acceptable salt thereof.

Structure Property Relationships of Carboxylic Acid Isosteres

The replacement of a carboxylic acid with a surrogate structure, or (bio)-isostere, is a classical strategy in medicinal chemistry. The general underlying principle is that by maintaining the features of the carboxylic acid critical for biological activity, but appropriately modifying the physicochemical properties, improved analogs may result. In this context, a systematic assessment of the physicochemical properties of carboxylic acid isosteres would be desirable to enable more informed decisions of potential replacements to be used for analog design. Herein we report the structure-property relationships (SPR) of 35 phenylpropionic acid derivatives, in which the carboxylic acid moiety is replaced with a series of known isosteres. The data set generated provides an assessment of the relative impact on the physicochemical properties that these replacements may have compared to the carboxylic acid analog. As such, this study presents a framework for how to rationally apply isosteric replacements of the carboxylic acid functional group.

OXAZOLO[5,4-C]QUINOLIN-2-ONE COMPOUNDS AS BROMODOMAIN INHIBITORS

The present invention relates to compounds useful as bromodomain inhibitors. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compounds and compositions in the treatment of various diseases and disorders.

Dihydroindolone compounds, a process for their preparation and pharmaceutical compositions containing them

Compounds of formula (I): wherein: m and n represent 1 or 2,A represents a pyrrolyl group,X represents a C(O), S(O) or SO2 group,R1 and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group,R3 and R4, together with the atoms carrying them, form a heterocyclic group,R5 represents a hydrogen atom or an alkyl group,R6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.

New heterocyclic inputs for the povarov multicomponent reaction

Oxa-, thia- and imidazolones are reactive inputs as electron-rich olefin components in Povarov reactions. On interaction with anilines and aldehydes, these substrates afford the corresponding multicomponent adducts in a regioselective manner. Intramolecular processes are also explored. Post-condensation oxidation provides convenient access to a variety of fused quinoline derivatives. Georg Thieme Verlag Stuttgart ? New York.

ARYLOXYALKYLCARBAMATE-TYPE DERIVATIVES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS

The invention relates to a compound of formula (I): [image] Wherein m, n, X, Y, R1, R2, R3 and R4 are as defined herein. The invention also relates to the use of same in therapeutics.

INDOLES HAVING ANTI-DIABETIC ACTIVITY

Indoles of Formula (I) having -X-aryl-(CH2)x#191-oxazolidinedione and -X-heteroaryl-(CH2)X-oxazolidinedione substituents on the N atom of the indole ring, where x is 0 or 1, and -X-is a bond or -CH2-, and their thiazolidinedione analogs, are PPAR gamma agonists or partial agonists and are useful in the treatment and control of type II diabetes, including hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

Electrolytic partial fluorination of organic compounds. Part 78: Regioselective anodic fluorination of 2-oxazolidinones

Various 2-oxazolidinones were galvanostatically electrooxidized in the presence of various fluoride salts. It was found that a fluorine atom was introduced to the α-position of the nitrogen atom of N-acyl- and N-alkoxycarbonyl-2-oxazolidinones to provide the corresponding α-fluorinated products in moderate to good yields. In the case of N-phenoxycarbonyl derivative, fluorination took place on the phenyl group selectively.

Tetraethylammonium hydrogen carbonate in organic synthesis: Synthesis of oxazolidine-2,4-diones

Oxazolidine-2,4-diones were synthesised by tetraethylammonium hydrogen (TEAHC) promoted carboxylation of secondary carboxamides bearing a leaving group at the α-position. Several oxazolidine-2,4-diones, including clinically used malidone, have been prepared in moderate to excellent yields as a results of a formal proton extraction-carboxylation- intramolecular S(N)2 one-pot sequence.