132657-47-7

Basic information

• Product Name: 4-[4-(dimethylamino)pyridinium-1-yl]butyl 2-ethoxy-3-(hexadecyloxy)propyl phosphate
• CAS NO: 132657-47-7
• Molecular Formula: C₃₂H₆₁N₂O₆P
• Molecular Weight: 600.8103
• Mol File: 132657-47-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[4-(dimethylamino)pyridinium-1-yl]butyl 2-ethoxy-3-(hexadecyloxy)propyl phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(dimethylamino)pyridinium-1-yl]butyl 2-ethoxy-3-(hexadecyloxy)propyl phosphate(132657-47-7)
• EPA Substance Registry System: 4-[4-(dimethylamino)pyridinium-1-yl]butyl 2-ethoxy-3-(hexadecyloxy)propyl phosphate(132657-47-7)

Safety Data

• Hazardous Substances Data: 132657-47-7(Hazardous Substances Data)

Upstream product

• 92758-87-7 3-(hexadecyloxy)-2-ethoxy-1-propanol 
• 1122-58-3 dmap 
• 139574-86-0 Phosphoric acid 4-bromo-butyl ester 2-ethoxy-3-hexadecyloxy-propyl ester 

Relevant articles and documents

PAF-antagonists with phospholipid structure. Part 2: Phospholipids with heteroarene head groups and variation of the P-N-distance; synthesis, characterization and structure-activity relationships

A series of 27 PAF-analogues with heteroarene head groups and variation of the P-N-distance on the C-3-position of the backbone were synthesized, and the PAF-antagonistic activity on human blood platelets in vitro was evaluated. Investigation of structure-activity relationships revealed that PAF-antagonistic activity is strongly influenced by the 4-(Dimethylamino)-pyridine as polar head base and the distance between phosphate group and onium center. Maximal activity was observed with a chain length of 3 or 4 methylene groups. Among the compounds tested, 1-O-Hexadecyl-2-n-propylpropan-1,3-diol-3-phosphoric acid-4'-[4-(dimethylamino)pyridinium]butylester was the most effective inhibitor in the in vitro assay (K(B) = 0,3 μmol/l).