1326591-07-4Relevant academic research and scientific papers
Highly stereoselective titanium-mediated aldol reactions from chiral α-silyloxy ketones. A reliable tool for the synthesis of natural products
Esteve, Judit,Jimenez, Carme,Nebot, Joaquim,Velasco, Javier,Romea, Pedro,Urpi, Flix
experimental part, p. 6045 - 6056 (2011/08/22)
Chiral α-silyloxy ketones participate in highly stereoselective TiCl4-mediated aldol reactions that afford diastereomerically pure syn-syn adducts in high yield irrespective of the R1 and R 2 substituents flanking the carbonyl or the silicon protecting group. Further manipulation of the resulting aldol adducts provide in a straightforward manner highly functionalized fragments that facilitate the synthesis of natural products.
