132672-20-9

Basic information

• Product Name: 4-Oxazolemethanol, a-(5-bromo-2-benzofuranyl)-5-methyl-2-phenyl-
• CAS NO: 132672-20-9
• Molecular Formula: C19H14BrNO3
• Molecular Weight: 384.229
• Mol File: 132672-20-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-Oxazolemethanol, a-(5-bromo-2-benzofuranyl)-5-methyl-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Oxazolemethanol, a-(5-bromo-2-benzofuranyl)-5-methyl-2-phenyl-(132672-20-9)
• EPA Substance Registry System: 4-Oxazolemethanol, a-(5-bromo-2-benzofuranyl)-5-methyl-2-phenyl-(132672-20-9)

Safety Data

• Hazardous Substances Data: 132672-20-9(Hazardous Substances Data)

Upstream product

• 1761-61-1 5-bromosalicyclaldehyde 
• 103788-62-1 4-bromoacetyl-5-methyl-2-phenyl-oxazole 
• 132646-31-2 (5-bromo-2-benzofuranyl)(5-methyl-2-phenyl-4-oxazolyl)methanone 

Downstream Products

• 132646-45-8 5-(2-(5-methyl-2-phenyloxazol-4-ylmethyl)-benzofuran-5-ylmethyl)-oxazolidine-2,4-dione 
• 132646-43-6 5-<2-<<(5-methyl-2-phenyl-4-oxazolyl)methyl>-5-benzofuranyl>methylidene>-2-thio-2,4-oxazolidinedione 
• 132646-44-7 5-<2-<<(5-methyl-2-phenyl-4-oxazolyl)methyl>-5-benzofuranyl>methylidene>-2,4-oxazolidinedione 
• 168632-28-8 5-[[2-[(5-methyl-2-phenyl-4-oxazolyl)hydroxymethyl]benzofuran-5-yl)methyl]-2,4-thiazolidinedione 
• 1026734-02-0 N-[2-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-ylmethyl]-hydroxylamine 
• 174258-63-0 1-[2-(5-methyl-2-phenyloxazol-4-ylmethyl)benzofuran-5-yl]ethanone 
• 174258-62-9 1-[2-(5-methyl-2-phenyloxazol-4-ylmethyl)benzofuran-5-yl]ethanol 
• 132646-33-4 2-<(5-methyl-2-phenyl-4-oxazolyl)methyl>benzofuran-5-carbonitrile 
• 132646-34-5 2-(5-methyl-2-phenyl-4-oxazolyl)methyl-5-benzofurancarboxaldehyde 
• 147046-94-4 2-[(5-methyl-2-phenyl-4-oxazolyl)-hydroxymethyl]-5-benzofurancarboxaldehyde 
• 132646-32-3 2-[(2-Phenyl-5-methyloxazol-4-yl)methyl]-5-bromobenzofuran 

Relevant articles and documents

Antihyperglycemic activity of new 1,2,4-oxadiazolidine-3,5-diones

A series of 1,2,4-oxadiazolidine-3,5-diones was synthesized and evaluated as oral antihyperglycemic agents in the obese insulin resistant db/db and ob/ob mouse - the two models for Type 2 diabetes mellitus. The majority of the prepared methoxy- and ethoxy-linked oxazole 1,2,4-oxadiazolidine-3,5-diones normalized plasma glucose levels at the 100 mg kg-1 oral dose in the db/db diabetic mouse model, and several amongst them reduced the glucose levels at the 20 mg kg-1 oral dose. The most potent compounds in the db/db mouse model were also active in the ob/ob mouse model normalizing the plasma glucose levels at the 20 mg kg-1 oral dose. The trifluoromethoxy analog 32 was the most active compound of the series, reducing significantly the plasma glucose levels at the 5 mg kg-1 oral dose. Oxadiazole-tailed 1,2,4-oxadiazolidine-3,5-diones were also active in both the db/db and ob/ob diabetic mouse models normalizing plasma glucose levels at the 100 mg kg-1 oral dose.

Thiazolidinedione hypoglycemic agents

Compounds of the formula STR1 where R is alkyl, cycloalkyl, phenyl or substituted phenyl are useful as hypoglycemic agents.

Oxazolidinedione hypoglycemic agents

Compounds of the formulae where R is cycloalkyl or aryl; R1 is alkyl, X is O or C=O; A is O or S; and B is N or CH are useful as hypoglycemic agents.