147046-94-4

Upstream product

• 132672-20-9 5-bromo-α-(5-methyl-2-phenyloxazol-4-yl)-2-benzofuranmethanol 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 168632-28-8 5-[[2-[(5-methyl-2-phenyl-4-oxazolyl)hydroxymethyl]benzofuran-5-yl)methyl]-2,4-thiazolidinedione 

Relevant academic research and scientific papers

Hypoglycemic activity of a series of α-alkylthio and α-alkoxy carboxylic acids related to ciglitazone

The thiazolidinedione moiety of ciglitazone and its analogues can be replaced by an α-alkoxy or α-thioether carboxylic acid group. The influence of the nature of the R group, the length of the connector to the aromatic backbone of the molecule, and the stereochemistry have been studied. The most potent compounds have glucose-lowering activity at doses as low as 0.01 mg/kg.

Thiazolidinedione hypoglycemic agents

Compounds of the formula STR1 where R is alkyl, cycloalkyl, phenyl or substituted phenyl are useful as hypoglycemic agents.