132683-27-3

Upstream product

• 105-53-3 diethyl malonate 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 

Downstream Products

• 179864-51-8 4-(3-{[(Ethoxycarbonyl)propyl]oxy}-4-methoxyphenyl)-2-pyrrolidinone 
• 104806-85-1 4-(3-{[(Carboxy)propyl]oxy}-4-methoxyphenyl)-2-pyrrolidinone 
• 57724-78-4 4-(3-benzyloxy-4-methoxyphenyl)-2-pyrrolidone 
• 57724-60-4 4-(3-hydroxy-4-methoxyphenyl)-pyrrolidin-2-one 

Relevant academic research and scientific papers

Synthesis of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines that have antibacterial activity and also inhibit inorganic pyrophosphatase

Inorganic pyrophosphatases are potential targets for the development of novel antibacterial agents. A pyrophosphatase-coupled high-throughput screening assay intended to detect o-succinyl benzoic acid coenzyme A (OSB CoA) synthetase inhibitors led to the unexpected discovery of a new series of novel inorganic pyrophosphatase inhibitors. Lead optimization studies resulted in a series of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazine derivatives that were prepared by an efficient synthetic pathway. One of the tetracyclic triazine analogues 22h displayed promising antibiotic activity against a wide variety of drug-resistant Staphylococcus aureus strains, as well as activity versus Mycobacterium tuberculosis and Bacillus anthracis, at a concentration that was not cytotoxic to mammalian cells.

5-phenyl-3-pyridazinone derivatives and drug composition containing the same

A 5-phenyl-3-pyridazinone derivative having the formula (I) wherein R1represents an unsubstituted or substituted C1to C8alkyl group, C3to C7cycloalkyl group, or indanyl group; R2represents