132685-71-3Relevant academic research and scientific papers
Synthesis, structure investigations, and antimicrobial activity of selected s-trans-6-aryl-4-isopropyl-2-{2-[(E)-1-phenylalkylidene]-(E)-hydrazino}-1,4- dihydropyrimidine hydrochlorides
Goessnitzer, Edith,Feierl, Gebhard,Wagner, Ute
, p. 49 - 61 (2007/10/03)
A series of 6-aryl-4-isopropyl-2-[2-(1-phenylalkylidene)hydrazino]-1,4-dihydropyrimidine hydrochlorides was prepared and tested for antibacterial and antifungal effects. The title compounds were synthesized by cyclocondensation of N2-(1-phenylalkylideneamino)guanidines with 1-aryl-4-methyl-2-penten-1-ones. Structure analyses of the prepared compounds were accomplished by means of 1D and 2D NMR spectroscopy. The analyses showed that the ring closure reaction took place regioselectively in all cases and generated exclusively 2-(phenylalkylidenehydrazino)dihydropyrimidines. According to the NOE experiments, the applied N2-(1-phenylalkylideneamino)guanidines exist in [D6]DMSO solution as s-trans-(E)- and the title compounds as s-trans-(E,E)-isomers. The antimicrobial activity was evaluated against representative Gram-negative and Gram-positive bacteria, and against the pathogenic yeast Candida albicans. The tested title compounds showed weak antibacterial activity against Gram-positive bacteria, and one compound was active against Candida albicans.
Guanylhydrazones of (hetero)aryl methyl ketones: Structure and reaction with acetic anhydride
Gyoergydeak, Zoltan,Holzer, Wolfgang,Mereiter, Kurt
, p. 899 - 913 (2007/10/03)
The synthesis of some novel guanylhydrazones of (hetero)aryl methyl ketones is described. Successive reaction with hot acetic anhydride leads to the corresponding N,N′-diacetyl derivatives. Structural assignments of all novel compounds and those of some a
