132705-51-2 Usage
Chemical Properties
white to off-white powder
Uses
Different sources of media describe the Uses of 132705-51-2 differently. You can refer to the following data:
1. A stable reagent for the coupling of N-Methylamino acids in peptide synthesis.
2. It can be used as a coupling reagent:For Suzuki–Miyaura cross-coupling of phenols and arylboronic acids to synthesize biaryls and heterobiaryls.To functionalize pyrimidines (synthesized from 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) via the Kappe dehydrogenation) by using various nucleophiles.To synthesize formamidines by coupling with various primary amines and N,N-diisopropylethylamine.It can also be used as an activating reagent:For the activation of C-OH bond in tautomerizable heterocycles to form the phosphonium salt which aids the Sonogashira coupling of heterocycles with various alkynes.For the one–pot activation of C-O bond in phenols and further coupling reaction with phosphine oxide or phosphite to form C-P bonds.
Check Digit Verification of cas no
The CAS Registry Mumber 132705-51-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,7,0 and 5 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 132705-51:
(8*1)+(7*3)+(6*2)+(5*7)+(4*0)+(3*5)+(2*5)+(1*1)=102
102 % 10 = 2
So 132705-51-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H24BrN3P.F6P/c13-17(14-7-1-2-8-14,15-9-3-4-10-15)16-11-5-6-12-16;1-7(2,3,4,5)6/h1-12H2;/q+1;-1
132705-51-2Relevant articles and documents
Controlled drug delivery system using the conjugation of drug to biodegradable polyester
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, (2008/06/13)
The present invention relates to the molecular sustained controlled release system constructed by the conjugation of molecules to be released with biodegradable polyester polymer via covalent bond and method for preparation thereof. In accordance with the present invention, the system may be formulated into microspheres, nanoparticles, or films. The molecular release rate from the above system can be regulated to be proportional to the chemical degradation rate of the biodegradable polyester polymers, resulting in near zero order kinetics profile of release without showing a burst effect. Moreover, the high loading efficiency of hydrophilic drugs can be achieved.
Cyclic AMP-specific phosphodiesterase inhibitors
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, (2008/06/13)
Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
