132709-17-2

Basic information

• Product Name: N-benzyl-2-phenylpropenamide
• Synonyms: N-benzyl-2-phenylpropenamide
• CAS NO: 132709-17-2
• Molecular Weight: 237.301
• Mol File: 132709-17-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: N-benzyl-2-phenylpropenamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-phenylpropenamide(132709-17-2)
• EPA Substance Registry System: N-benzyl-2-phenylpropenamide(132709-17-2)

Safety Data

• Hazardous Substances Data: 132709-17-2(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 536-74-3 phenylacetylene 
• 100-46-9 benzylamine 
• 492-38-6 2-phenylacrylic acid 
• 51491-68-0 2-phenylacrylyl chloride 
• 7500-45-0 N-benzylphenylacetamide 
• 68-12-2 N,N-dimethyl-formamide 
• 529-64-6 Tropic acid 

Downstream Products

• 1414882-58-8 (2E,4Z)-n-butyl 6-benzylamino-5-phenyl-6-oxohexa-2,4-dienoate 
• 1414882-82-8 (2E,4Z)-tert-butyl 6-benzylamino-5-phenyl-6-oxohexa-2,4-dienoate 
• 1233241-15-0 C₁₈H₁₉NO₃ 

Relevant articles and documents

Small-Molecule Inhibitors Targeting Sterol 14α-Demethylase (CYP51): Synthesis, Molecular Modelling and Evaluation Against Candida albicans

Fungal infections are a global issue affecting over 150 million people worldwide annually, with 750 000 of these caused by invasive Candida infections. Azole drugs are the frontline treatment against fungal infections; however, resistance to current azole

Effect of Transition Metals on Chemodivergent Cross-Coupling of Acrylamides with Vinyl Acetate via C-H Activation

A novel chemodivergent cross-coupling of acrylamides and vinyl acetates has been realized via metal-catalyzed vinylic C-H activation. The selective olefinic C-H vinylation and alkenylation reaction was examined with a variety of differently functionalized acrylamides. The reaction efficiently generates a range of highly synthetically valuable butadienes with good functional group tolerance in good to moderate yields. A possible catalytic reaction mechanism involving the chelation-assisted olefinic C-H activation via an acetate-assisted deprotonation pathway is proposed.

Design of oxa-spirocyclic PHOX ligands for the asymmetric synthesis of lorcaserin: Via iridium-catalyzed asymmetric hydrogenation

Phosphine-oxazoline (PHOX) ligands are a very important class of privileged ligands in asymmetric catalysis. A series of highly rigid oxa-spiro phosphine-oxazoline (O-SIPHOX) ligands based on O-SPINOL was synthesized efficiently, and their iridium complexes were synthesized by coordination of the O-SIPHOX ligands to [Ir(cod)Cl]2 in the presence of sodium tetrakis-3,5-bis(trifluoromethyl)phenylborate (NaBArF). The cationic iridium complexes showed high reactivity and excellent enantioselectivity in the asymmetric hydrogenation of 1-methylene-tetrahydro-benzo[d]azepin-2-ones (up to 99% yield and up to 99% ee). A key intermediate of the anti-obesity drug lorcaserin could be efficiently synthesized using this protocol.