132715-17-4

Basic information

• Product Name: (2S,4R)-methyl 1-(2-chloroacetyl)-4-hydroxypyrrolidine-2-carboxylate
• Synonyms: (2S,4R)-methyl 1-(2-chloroacetyl)-4-hydroxypyrrolidine-2-carboxylate
• CAS NO: 132715-17-4
• Molecular Weight: 221.641
• Mol File: 132715-17-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S,4R)-methyl 1-(2-chloroacetyl)-4-hydroxypyrrolidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-methyl 1-(2-chloroacetyl)-4-hydroxypyrrolidine-2-carboxylate(132715-17-4)
• EPA Substance Registry System: (2S,4R)-methyl 1-(2-chloroacetyl)-4-hydroxypyrrolidine-2-carboxylate(132715-17-4)

Safety Data

• Hazardous Substances Data: 132715-17-4(Hazardous Substances Data)

Upstream product

• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 1429196-88-2 (7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]-2-{[2-(trifluoromethyl)phenyl]-sulfonyl}octahydropyrrolo[1,2-a]pyrazine 
• 1429199-72-3 (7R,8aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}-7-{[5-(trifluoromethyl)-pyridin-2-yl]oxy}octahydropyrrolo[1,2-a]pyrazine 
• 1429199-52-9 (7R,8aS)-7-{[5-(1-methylcyclopropyl)pyrazin-2-yl]oxy}-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydropyrrolo[1,2-a]pyrazine 
• 1429197-82-9 (7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]-2-{[3-(1,1-difluoroethyl)-phenyl]sulfonyl}octahydropyrrolo[1,2-a]pyrazine 
• 1429197-81-8 1-(3-{[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]-pyrazin-2(1H)-yl]sulfonyl}phenyl)ethanone 
• 1429197-25-0 3-{ [(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]-pyrazin-2(1H)-yl]sulfonyl}-5-(trifluoromethyl)benzonitrile 
• 1429197-86-3 (7R,8aS)-2-{[3-bromo-5-(trifluoromethyl)phenyl]sulfonyl}-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine 
• 1429197-23-8 (7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]-2-[(2,4-difluorophenyl)-sulfonyl]octahydropyrrolo[1,2-a]pyrazine 
• 1429197-18-1 (7R,8aS)-2-[(3-tert-butyl-4-methoxyphenyl)sulfonyl]-7-[(5-cyclopropyl-pyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine 
• 1429295-25-9 [(7R,8aS)-7-[(5-chloropyridin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl][3-(trifluoromethyl)phenyl]methanone 
• 1429295-24-8 [(7R,8aS)-7-hydroxyhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl][3-(trifluoromethyl)phenyl]methanone 
• 1443034-63-6 [(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl][4-fluoro-3-(trifluoromethyl)phenyl]methanone 
• 1429199-84-7 (7R,8aS)-2-benzyl-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine 
• 1429296-40-1 1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-(methylamino)-2-[3-(trifluoromethyl)phenyl]ethanone 

Relevant articles and documents

SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS

The present application relates to: (a) compounds of Formula (I): (I), and salts thereof, wherein Z1, Z2, Z3, Z4, R1, R2, and R3 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel inhibitors.

8-Hydroxylated Derivatives of Diazabicyclononanes, 2,5-Dioxodiazabicyclononanes and Some Related Esters

Pharmacological considerations promted the authors to synthesize a series of 8-hydroxylated optically active derivatives of diazabicyclononanes and of their 2,5-dioxo analogs from trans-4-hydroxy-L-proline.Esterification with appropriate anhydrides led to the corresponding esters with 6S,8R configuration.Inversion of configuration at C-8 was performed using Mitsunobu method and led to the diastereoisomeric series of 6S,8S esters.A tentative pharmacological evaluation was carried out in the area of sedative and spasmolytic activities.