1327157-90-3Relevant articles and documents
Stereoselective synthesis of (+)-(8R,8aR)-perhydro-8-indolizidinol
Kumar, R. Sateesh Chandra,Reddy, G. Venkateswar,Babu, K. Suresh,Rao, J. Madhusudana
, p. 4382 - 4384 (2011/09/19)
A highly stereoselective total synthesis of (+)-(8R,8aR)-perhydro-8- indolizidinol is described. Key steps involved in this synthesis are diastereoselective zinc allylation, azido-olefin cyclization and reductive amination followed by cyclization which effectively constructed the indolizidine ring. This contributes a unique approach to the synthesis of indolizidine alkaloids that offers the advantages of brevity and relatively high overall yields.