741703-35-5

Upstream product

• 1013212-24-2 (1R)-1-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-3-butenyl azide 
• 1327157-88-9 C₂₁H₂₅NO₆S 
• 1327157-89-0 C₂₀H₂₇NO₄ 
• 196090-72-9 Toluene-4-sulfonic acid (S)-(R)-1-(1,4-dioxa-spiro[4.5]dec-2-yl)-but-3-enyl ester 
• 623938-46-5 (2R)-(+)-phenylmethyl 2-vinylpyrrolidine-1-carboxylate 

Downstream Products

• 905946-84-1 phenylmethyl (2R,1'S)-2-(2-acetyl-sulfanil-1-hydroxyethyl)pyrrolidine-1-carboxylate 
• 1327157-86-7 C₁₆H₂₃NO₄ 
• 1327157-90-3 C₂₃H₂₉NO₆S 
• 1327157-87-8 (R)-benzyl 2-((R)-1-hydroxypent-4-en-1-yl)pyrrolidine-1-carboxylate 
• 882425-33-4 phenylmethyl (2R,1'S)-2-(1-hydroxy-2-mercaptoethyl)pyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

Stereoselective synthesis of (+)-(8R,8aR)-perhydro-8-indolizidinol

A highly stereoselective total synthesis of (+)-(8R,8aR)-perhydro-8- indolizidinol is described. Key steps involved in this synthesis are diastereoselective zinc allylation, azido-olefin cyclization and reductive amination followed by cyclization which effectively constructed the indolizidine ring. This contributes a unique approach to the synthesis of indolizidine alkaloids that offers the advantages of brevity and relatively high overall yields.

Highly chiral muscarinic ligands: The discovery of (2S,2′R,3′S, 5′R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist

By further steric complication of previously studied highly chiral muscarinic agonists, we have obtained a small chiral library of enantiomeric and diasteromeric 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxides. Binding studies on cloned