132719-10-9

Basic information

• Product Name: Ethanone, 1-(3,5-dimethylphenyl)-2,2,2-trifluoro- (9CI)
• Synonyms: Ethanone, 1-(3,5-dimethylphenyl)-2,2,2-trifluoro- (9CI)
• CAS NO: 132719-10-9
• Molecular Formula: C₁₀H₉F₃O
• Molecular Weight: 202.1730696
• Product Categories: ACETYLHALIDE
• Mol File: 132719-10-9.mol

Chemical Properties

• Boiling Point: 222.4°Cat760mmHg
• Flash Point: 98.3°C
• Appearance: /
• Density: 1.189g/cm³
• Vapor Pressure: 0.102mmHg at 25°C
• Refractive Index: 1.458
• CAS DataBase Reference: Ethanone, 1-(3,5-dimethylphenyl)-2,2,2-trifluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(3,5-dimethylphenyl)-2,2,2-trifluoro- (9CI)(132719-10-9)
• EPA Substance Registry System: Ethanone, 1-(3,5-dimethylphenyl)-2,2,2-trifluoro- (9CI)(132719-10-9)

Safety Data

• Hazardous Substances Data: 132719-10-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Ethanone, 1-(3,5-dimethylphenyl)-2,2,2-trifluoro(9CI) serves as a valuable reagent in organic synthesis, leveraging its unique properties to facilitate various chemical reactions and the formation of new compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, Ethanone, 1-(3,5-dimethylphenyl)-2,2,2-trifluoro- (9CI) plays a crucial role in research and development. Its distinctive structure and properties make it a promising candidate for the creation of new drugs and medicinal agents, contributing to advancements in healthcare and treatment options.

InChI:InChI=1/C10H9F3O/c1-6-3-7(2)5-8(4-6)9(14)10(11,12)13/h3-5H,1-2H3

Upstream product

• 34696-73-6 3,5-dimethyphenylmagnesium bromide 
• 407-25-0 trifluoroacetic anhydride 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 556-96-7 5-bromo-1,3-xylene 
• 13081-18-0 ethyl-3,3,3-trifluoropyruvate 
• 104863-67-4 N-methoxy-N-methyltrifluoroacetamide 

Downstream Products

• 1422985-06-5 (E)-1,3-dimethyl-5-(3,3,3-trifluoro-1-nitroprop-1-en-2-yl)benzene 
• 1422985-25-8 3-(2-(3,5-dimethylphenyl)-1,1,1-trifluoro-3-nitropropan-2-yl)-1H-indole 
• 1422984-87-9 C₁₁H₁₂F₃NO₃ 
• 1402403-22-8 C₂₁H₁₉F₃O₃ 
• 1391837-94-7 2-(3,5-dimethylphenyl)-2-(trifluoromethyl)-2H-pyran-4(3H)-one 
• 1340475-21-9 ethyl 4,4,4-trifluoro-3-hydroxy-3-(3,5-dimethylphenyl)-2-diazobutanoate 

Relevant articles and documents

Copper-Mediated Trifluoroacetylation of Arenediazonium Salts with Ethyl Trifluoropyruvate

A copper-mediated trifluoroacetylation of various arenediazonium salts with ethyl trifluoropyruvate is reported. The reaction proceeded smoothly under mild conditions at room temperature giving trifluoromethyl aryl ketones in moderate to good yields. A variety of functional groups, including methoxy, hydroxy, ester, ketone, trifluoromethyl, and halide groups, were well tolerated. A possible reaction mechanism involving an aryl radical intermediate was proposed and supported by experimental evidence. This reaction provides a new route to trifluoromethyl aryl ketones, notable synthetic targets, from the corresponding anilines.

A coupling of benzamides and donor/acceptor diazo compounds to form γ-lactams via Rh(III)-catalyzed C-H activation

The coupling of O-pivaloyl benzhydroxamic acids with donor/acceptor diazo compounds provides isoindolones in high yield. The reaction tolerates a broad range of benzhydroxamic acids and diazo compounds, including substituted 2,2,2-trifluorodiazoethanes. Mechanistic experiments suggested that C-H activation is turnover-limiting and irreversible and that insertion of the diazo compound favors electron-deficient substrates.

Photoaffinity labeling on magnetic microspheres (PALMm) methodology for topographic mapping: Preparation of PALMm reagents and demonstration of biochemical relevance

Photoaffinity labeling (PAL) is a technique widely used for identifying the binding-site within proteins. Although the classic method is both versatile and powerful, it suffers significant disadvantages, such as the need to radiolabel the PAL ligand, and the need to conduct highly complicated separations of both the labeled protein and the labeled peptides derived from it. Here, we propose a novel and universal methodology - Photo-Affinity Labeling on Magnetic microspheres (PALMm) designed to simplify and shorten the PAL protocol. In this context, we describe the preparation of PALMm reagents and the evaluation of their biochemical relevance regarding two ATP-binding enzymes: hexokinase and apyrase.