104863-67-4

Basic information

• Product Name: N-METHOXY-N-METHYLTRIFLUOROACETAMIDE
• Synonyms: N-METHYL-N-METHOXYTRIFLUOROACETAMIDE;N-METHOXY-N-METHYLTRIFLUOROACETAMIDE;N-METHOXY-N-METHYL-2,2,2-TRIFLUOROACETAMIDE;N-Methoxy-N-methyltrifluoroacetamide 98%;N-Methoxy-N-methyltrifluoroacetamide98%;4-Methoxy-3-methylthiophenol;N-Methoxy-N-methyl-2,2,2-trifluoroacetamide 98%;N-Methoxy-N-(trifluoroacetyl)methylamine, N-Methoxy-N-methyl-2,2,2-trifluoroacetamide
• CAS NO: 104863-67-4
• Molecular Formula: C₄H₆F₃NO₂
• Molecular Weight: 157.09
• Mol File: 104863-67-4.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 53 °C30 mm Hg(lit.)
• Flash Point: 118 °F
• Appearance: /
• Density: 1.299 g/mL at 25 °C(lit.)
• Vapor Pressure: 259mmHg at 25°C
• Refractive Index: 1.3630 to 1.3670
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N-METHOXY-N-METHYLTRIFLUOROACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHOXY-N-METHYLTRIFLUOROACETAMIDE(104863-67-4)
• EPA Substance Registry System: N-METHOXY-N-METHYLTRIFLUOROACETAMIDE(104863-67-4)

Safety Data

• Hazard Codes: T,Xi
• Statements: 10-25-36
• Safety Statements: 16-26-45
• RIDADR: UN 1992 3/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 104863-67-4(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless liquid

InChI:InChI=1/C4H6F3NO2/c1-8(10-2)3(9)4(5,6)7/h1-2H3

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 76-05-1 trifluoroacetic acid 
• 407-25-0 trifluoroacetic anhydride 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 354-32-5 trifluoracetyl chloride 

Downstream Products

• 217438-93-2 (S)-3-((S)-1-Cyclohexylmethyl-3,3,3-trifluoro-2-oxo-propyl)-4-phenyl-oxazolidin-2-one 
• 609806-82-8 1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-one 
• 400-31-7 1,1,1-trifluoro-4-methyl-pent-3-en-2-one 
• 1599529-24-4 2,2,2-trifluoro-1-(2-fluoro-5-((4-fluorophenyl)(hydroxy)methyl)phenyl)ethanone 
• 86571-26-8 1,1,1-trifluoro-4-phenylbutan-2-one 
• 1026730-55-1 (6-benzyloxyhexyl)trifluoromethyl ketone 
• 26902-72-7 1,1,1-Trifluorododecan-2-one 
• 1800-42-6 2-naphthyl trifluoromethyl ketone 
• 6302-04-1 1-cyclohexyl-2,2,2-trifluoroethanone 
• 886370-18-9 1-(3-chloro-4-methylphenyl)-2,2,2-trifluoroethanone 
• 34773-51-8 2-bromo-5-(2′,2′,2′-trifluoroethanonyl)-thiophene 
• 85674-68-6 1,1,1-trifluoro-5-phenyl-pentan-2-one 

Relevant articles and documents

Economical and practical strategies for synthesis of α-trifluoromethylated amines

A powerful approach to synthesize α-trifluoromethylated amines has been developed. The method is operationally simple, broad in substrate scope and amenable to scale-up using trifluoroacetic anhydride. Meanwhile, the strategy not only provided a versatile approach to synthesize α-trifluoromethylated amines but also provides a new method for exploring the new reactivity of trifluoroacetic anhydride.

Synthesis, X-ray Structure Determination, and Comprehensive Photochemical Characterization of (Trifluoromethyl)diazirine-Containing TRPML1 Ligands

Potential (trifluoromethyl)diazirine-based TRPML1 ion channel ligands were designed and synthesized, and their structures were determined by single-crystal X-ray diffraction analysis. Photoactivation studies via 19F NMR spectroscopy and HPLC-MS analysis revealed distinct kinetical characteristics in selected solvents and favorable photochemical properties in an aqueous buffer. These photoactivatable TRPML activators represent useful and valuable tools for TRPML photoaffinity labeling combined with mass spectrometry.

Synthesis of trifluoromethyl moieties by late-stage copper (I) mediated nucleophilic fluorination

The nucleophilic fluorination of bromodifluoromethyl derivatives mediated by the complex (PPh3)3CuF is described. Under the reaction conditions, different trifluoroacetates, trifluoroketones, trifluoroarenes and trifluoroacetamides were obtained in good yields.