1327278-70-5Relevant articles and documents
Synthesis of 3-tert-butyl-5-(4-vinylphenyl)-1,2,4-oxadiazole using two different pathways
Maftei, Catalin-Vasile,Fodor, Elena,Mangalagiu, Ionel,Jones, Peter G.,Daniliuc, Constantin-Gabriel,Franz, Heiko M.,Neda, Ion
, p. 989 - 994 (2012/01/19)
3-tert-butyl-5-(4-vinylphenyl)-1,2,4-oxadiazole (1) has been synthesized in two different ways, using 3-tert-butyl-5-(4-ethynylphenyl)-1,2,4-oxadiazole (2) or 4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)benzaldehyde (3) as intermediates. The structure of compound 3 was confirmed by X-ray diffraction. 1,2,4-Oxadiazoles have been prepared using 1,1-carbonyldiimidazole (CDI) as a reagent for both formation and cyclodehydration of O-acyl-amidoximes. The use of CDI facilitates parallel purification of the oxadiazole products by simple liquid-liquid extraction and filtration. The heterocycles were obtained in good yields and in relatively short reaction times.