1327278-72-7

Basic information

• Product Name: 3-tert-butyl-5-(4-ethylphenyl)-1,2,4-oxadiazole
• Synonyms: 3-tert-butyl-5-(4-ethylphenyl)-1,2,4-oxadiazole
• CAS NO: 1327278-72-7
• Molecular Weight: 230.31
• Mol File: 1327278-72-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-tert-butyl-5-(4-ethylphenyl)-1,2,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-tert-butyl-5-(4-ethylphenyl)-1,2,4-oxadiazole(1327278-72-7)
• EPA Substance Registry System: 3-tert-butyl-5-(4-ethylphenyl)-1,2,4-oxadiazole(1327278-72-7)

Safety Data

• Hazardous Substances Data: 1327278-72-7(Hazardous Substances Data)

Upstream product

• 1327278-70-5 3-tert-butyl-5-(4-ethynylphenyl)-1,2,4-oxadiazole 
• 42956-75-2 N'-hydroxypivalimidamide 
• 586-76-5 4-Bromobenzoic acid 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 10602-00-3 4-Ethynyl-benzoic acid 
• 33577-98-9 methyl 4-(3-hydroxy-3-methylbut-1-ynyl)benzoate 

Relevant articles and documents

Synthesis of 3-tert-butyl-5-(4-vinylphenyl)-1,2,4-oxadiazole using two different pathways

3-tert-butyl-5-(4-vinylphenyl)-1,2,4-oxadiazole (1) has been synthesized in two different ways, using 3-tert-butyl-5-(4-ethynylphenyl)-1,2,4-oxadiazole (2) or 4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)benzaldehyde (3) as intermediates. The structure of compound 3 was confirmed by X-ray diffraction. 1,2,4-Oxadiazoles have been prepared using 1,1-carbonyldiimidazole (CDI) as a reagent for both formation and cyclodehydration of O-acyl-amidoximes. The use of CDI facilitates parallel purification of the oxadiazole products by simple liquid-liquid extraction and filtration. The heterocycles were obtained in good yields and in relatively short reaction times.