132733-95-0

Upstream product

• 16255-50-8 1-nitro-2,5-bis-(chloromethyl)benzene 
• 106-42-3 para-xylene 
• 623-25-6 p-Xylylene dichloride 
• 89-58-7 mononitro-p-xylene 

Downstream Products

• 290354-09-5 C₂₈H₄₅N₅O₄ 
• 290354-11-9 C₃₀H₄₉N₅O₃ 
• 290354-10-8 C₂₈H₄₇N₅O₂ 

Relevant academic research and scientific papers

Rapid and efficient solvent-free synthesis of cyclophanes based on bipyridinium under mechanical ball milling

We reported here the first rapid and solvent-free template-directed preparation of cyclophanes based on bipyridinium, which was achieved using mechanical ball milling. The method affords a new strategy for construction of diverse substituted CBPQT·4PF6, which greatly shortens the reaction period, rendering this methodology practical in the field of supermolecular chemistry.

New carbamoylpiperidines as human platelet aggregation inhibitors

A series of 3-carbamoylpiperidines (nipecotamides) are designed, synthesized and tested for their inhibitory action against adenosine diphosphate (ADP)-induced aggregation of human platelets. A structure- activity analysis of the bis(nipecotamido)aralkane type showed that a substituent on the piperidine ring should preferably be an amide and that the electronegativity of the carbonyl oxygen and the orientation of the amide group affected activities. Based on the knowledge of factors influencing platelet activation and aggregation, a nitric ester moiety which could release nitric oxide (NO) in situ, is incorporated into the nipecotamide structure. These compounds exhibit increased activity compared to those having no -ONO2 function. They also show stereoselectivity, with the meso isomer being approximately twice as potent as the synthetic diastereomeric mixture. Replacement of the -ONO2 function with hydroxyl, ester or alkyl groups considerably diminishes aggregation-inhibitory potential. Nipecotamides are shown here to inhibit the basal and collagen-induced rise in platelet inositol trisphosphate (IP3) levels, as well as phosphoinositide turnover. A comprehensive mechanism of action is proposed taking earlier results into consideration. (C) 2000 Elsevier Science Ltd.

The first electron-donor-acceptor paracyclophanes with ferrocene NLO-phores: Synthesis, absorption and electrochemical properties

As potential nonlinear optical materials, 12-nitro-4,7-bis(2-ferrocenylvinyl)[2.2]paracyclophane (1) and 12-nitro-4,5,7,8-tetrakis(2-ferrocenylvinyl)[2.2]paracyclophane (2) have been synthesized by Pd-catalyzed coupling reactions of vinylferro-cene with the precursor cyclophanes 9 and 13, respectively. The absorption and electrochemical properties of 1 and 2 are also described. VCH Verlagsgesellschaft mbH.