13274-46-9Relevant academic research and scientific papers
Investigating Bicyclobutane-Triazolinedione Cycloadditions as a Tool for Peptide Modification
Gardiner, Michael G.,Malins, Lara R.,Nashar, Philippe E.,Schwartz, Brett D.,Smyth, Aidan P.
supporting information, (2022/02/07)
Acyl bicyclobutanes are shown to engage in strain-promoted cycloaddition reactions with a diverse array of triazolinedione reagents. The synthesis of an orthogonally protected urazole building block enabled the facile preparation of amino acid- and peptid
Urazole synthesis. Part 2: Facilitating N4 substitution
Chai, Weirui,Nguyen, Emily,Doran, Jennifer,Han, Katie,Weatherbie, Alexander,Fernandez, Daniel,Karimi, Sarah,Mynam, Ritwick,Humphrey, Caroline,Rana, Sara,Buynak, John D.
, p. 2308 - 2310 (2013/06/26)
The di-tert-butyl-di-p-nitrophenyl ester of hydrazinetetracarboxylic acid was prepared and shown to be useful in the preparation of urazoles (i.e., 1,2,4-triazolidine-3,5-diones), by reaction with a primary amine using either n-BuLi or pyridine as base, d
Synthesis of 1,2,4-triazole dendrimers
Maes, Wouter,Verstappen, Bert,Dehaen, Wim
, p. 2677 - 2683 (2007/10/03)
A convergent synthetic strategy towards novel 1,2,4-triazole dendrimers, in which 3,5-dichloro-4-(4-methoxyphenyl)-4H-1,2,4-triazole was used as the heterocyclic building block, was successfully explored. Nucleophilic aromatic substitution at this novel A
Proton-Transfer Chemistry of Urazoles and Related Imides, Amides, and Diacyl Hydrazides
Bausch, M. J.,David, B.,Dobrowolski, P.,Guadalupe-Fasano, C.,Gostowski, R.,et al.
, p. 5643 - 5651 (2007/10/02)
Equilibrium acidity constants have been determined for 1,2,4-triazolidine-3,5-dione (urazole), several substituted urazoles, and other related acids, in both dimethyl sulfoxide (DMSO) and aqueous solution.In DMSO, urazole has a pKa of 13.1.In w
