16253-60-4

Upstream product

• 725-12-2 2,5-bis-(phenyl)-1,3,4-oxadiazole 
• 104-94-9 4-methoxy-aniline 
• 883627-37-0 3,5-dichloro-4-(4-methoxyphenyl)-4H-1,2,4-triazole 
• 98-80-6 phenylboronic acid 
• 787-84-8 N'-benzoylbenzohydrazide 
• 13274-46-9 4-(4-methoxyphenyl)urazole 
• 5416-93-3 4-Methoxyphenyl isocyanate 
• 13482-67-2 ethyl 2-((4-methoxyphenyl)carbamoyl)hydrazinecarboxylate 

Relevant academic research and scientific papers

A novel synthesis of 3,4,5-triaryl-1,2,4-4H-triazoles from 2,5-diaryl-1,3,4-oxadiazoles and aluminium anilides

3,4,5-Triaryl-1,2,4-4H-triazoles have been prepared in 70-91% yields by a simple and easy to control one-pot procedure from 2,5- diaryl-1,3,4-oxadiazoles and aluminium anilides.

A ceric ammonium nitrate N-dearylation of N-p-anisylazoles applied to pyrazole, triazole, tetrazole, and pentazole rings: Release of parent azoles. Generation of unstable pentazole, HN5/N5-, in solution

(Chemical Equation Presented) The reaction of cerium(IV) ammonium nitrate (CAN) with a range of N-(p-anisyl)azoles in acetonitrile or methanol solvents leads to N-dearylation releasing the parent NH-azole and p-benzoquinone in comparable yields. The scope and limitations of the reaction are explored. It was successful with 1-(p-anisyl)pyrazoles, 2-(p-anisyl)-1,2,3-triazoles, 2-(p-anisyl)-2H-tetrazoles, and 1-(p-anisyl)pentazole. The dearylation renders the p-anisyl group as a potentially useful N-protecting group in azole chemistry. The azole released in solution from 1-(p-anisyl)pentazole is unstable HN5, the long-sought parent pentazolic acid. p-Anisylpentazole samples were synthesized with combinations of one, two, and three 15N atoms at all positions of the pentazole ring. The unstable HN 5/N5- produced at -40°C did not build up in the solution but degraded to azide ion and nitrogen gas with a short lifetime. The 15N-labeling of the N3- ion obtained from all samples proved unequivocally that it came from the degradation of HN 5 (tautomeric forms) and/or its anion N5- in the solution.

Synthesis of 1,2,4-triazole dendrimers

A convergent synthetic strategy towards novel 1,2,4-triazole dendrimers, in which 3,5-dichloro-4-(4-methoxyphenyl)-4H-1,2,4-triazole was used as the heterocyclic building block, was successfully explored. Nucleophilic aromatic substitution at this novel A