132741-81-2 Usage
Description
5,6-Methylenedioxy-2-aminoindan is an organic compound with a chemical structure that includes a central indan ring, which is a seven-membered ring with a fusion of a benzene ring. It has a 2-amino group and two methoxy groups attached to the 5,6-positions of the benzene ring. 5,6-methylenedioxy-2-aminoindan is a pink to pale purple solid and is known for its stimulant properties, making it similar to amphetamines.
Uses
Used in Pharmaceutical Industry:
5,6-Methylenedioxy-2-aminoindan is used as a central nervous system stimulant for its ability to increase alertness, attention, and energy levels. Its stimulant properties make it a potential candidate for the treatment of conditions such as attention deficit hyperactivity disorder (ADHD), narcolepsy, and other disorders that require enhanced cognitive function and wakefulness.
Used in Research and Development:
Due to its structural similarity to amphetamines, 5,6-methylenedioxy-2-aminoindan can be utilized in research and development for the creation of new drugs with improved efficacy and reduced side effects. It can also be used to study the mechanisms of action of stimulant drugs and their effects on the central nervous system.
Used in Forensic Science:
The identification and analysis of 5,6-methylenedioxy-2-aminoindan can be relevant in forensic science, particularly in cases involving the detection and analysis of controlled substances. Its unique chemical properties and appearance can aid in the differentiation and identification of various compounds in forensic investigations.
Used in Quality Control and Analysis:
5,6-Methylenedioxy-2-aminoindan can be employed in the quality control and analysis of pharmaceutical products, ensuring the presence of the desired active ingredient and monitoring its purity. This is crucial for maintaining the safety, efficacy, and consistency of medications containing this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 132741-81-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,7,4 and 1 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 132741-81:
(8*1)+(7*3)+(6*2)+(5*7)+(4*4)+(3*1)+(2*8)+(1*1)=112
112 % 10 = 2
So 132741-81-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H11NO2/c11-8-1-6-3-9-10(13-5-12-9)4-7(6)2-8/h3-4,8H,1-2,5,11H2
132741-81-2Relevant articles and documents
INDOLE AHR INHIBITORS AND USES THEREOF
-
, (2018/11/22)
The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
Nonneurotoxic Tetralin and Indian Analogues of 3,4-(Methylenedioxy)amphetamine (MDA)
Nichols, David E.,Brewster, William K.,Johnson, Michael P.,Oberlender, Robert,Riggs, Robert M.
, p. 703 - 710 (2007/10/02)
Four cyclic analgues of the psychoactive phenethylamine derivative 3,4-(methylenedioxy)amphetamine were studied.These congeners, 5,6- and 4,5-(methylenedioxy)-2-aminoindan (3a and 4a, respectively), and 6,7- and 5,6-(methylenedioxy)-2-aminotetralin (3b and 4b, respectively) were tested for stimulus generalization in the two-lever drug-discrimination paradigm.Two groups of rats were trained to discriminate either LSD tartrate (0.08 mg/kg) from saline, or (+/-)-MDMA*HCl (1.75 mg/kg) from saline.In addition, a 2-aminoindan (5a) and 2-aminotetralin (5b) congener of the hallucinogenic amphetamine 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) were also evaluated.None of the methylenedioxy compounds substituted in LSD-trained rats, while both 3a and 3b fully substituted in MDMA-trained rats.Compounds 4a and 4b did not substitute in MDMA-trained rats.Compounds 5a and 5b did not substitute in MDMA-trained rats, although 5a substituted in LSD-trained rats, but with relatively low potency compared to its open-chain counterpart.In view of the now well-established serotonin neurotoxicity of 3,4-(methylenedioxy)amphetamine and its N-methyl homologue 1, 3a and 3b were evaluated and compared to 1 for similar toxic effects following a single acute dose of 40 mg/kg sc.Sacrifice at 1 week showed that neither 3a nor 3b depressed rat cortical or hippocampal 5-HT or 5-HIAA levels nor were the number of binding sites (Bmax) depressed for paroxetine.By contrast, and in agreement with other reports, 1 significantly depressed all three indices of neurotoxicity.These results indicate that 3a and 3b have acute behavioral pharmacology similar to 1 but that they lack similar serotonin neurotoxicity.
This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.