13277-74-2

Basic information

• Product Name: DIETHYL 2,4-DIACETYL-3-PHENYLPENTANEDIOATE
• Synonyms: DIETHYL 2,4-DIACETYL-3-PHENYLPENTANEDIOATE
• CAS NO: 13277-74-2
• Molecular Formula: C₁₉H₂₄O₆
• Molecular Weight: 348.39
• Mol File: 13277-74-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 467.3°Cat760mmHg
• Flash Point: 203.1°C
• Appearance: /
• Density: 1.136g/cm³
• Vapor Pressure: 6.59E-09mmHg at 25°C
• Refractive Index: 1.5
• Storage Temp.: 2-8°C
• CAS DataBase Reference: DIETHYL 2,4-DIACETYL-3-PHENYLPENTANEDIOATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL 2,4-DIACETYL-3-PHENYLPENTANEDIOATE(13277-74-2)
• EPA Substance Registry System: DIETHYL 2,4-DIACETYL-3-PHENYLPENTANEDIOATE(13277-74-2)

Safety Data

• Hazardous Substances Data: 13277-74-2(Hazardous Substances Data)

Usage

General Description

DIETHYL 2,4-DIACETYL-3-PHENYLPENTANEDIOATE is a chemical compound with the molecular formula C16H20O6. It is commonly used in the production of flavor and fragrance compounds, as it has a sweet, fruity aroma. DIETHYL 2,4-DIACETYL-3-PHENYLPENTANEDIOATE is often employed in the manufacturing of food products, cosmetics, and perfumes. It is known for its ability to enhance the flavor and scent of various consumer goods. Additionally, DIETHYL 2,4-DIACETYL-3-PHENYLPENTANEDIOATE is also used in the pharmaceutical industry as an intermediate for synthesizing various medications. Overall, this chemical compound has a wide range of applications in the fields of food and beverage, personal care, and pharmaceuticals.

InChI:InChI=1/C19H24O6/c1-5-24-18(22)15(12(3)20)17(14-10-8-7-9-11-14)16(13(4)21)19(23)25-6-2/h7-11,15-17H,5-6H2,1-4H3

Upstream product

• 141-97-9 ethyl acetoacetate 
• 100-52-7 benzaldehyde 

Downstream Products

• 4165-96-2 3-phenylglutaric acid 
• 6456-86-6 4-(aminocarbonyl)-3-phenylbutanoic acid 

Relevant articles and documents

Novel amide derivatives of 3-phenylglutaric acid as potent soluble epoxide hydrolase inhibitors

Abstract: Soluble epoxide hydrolase (sEH) enzyme plays an important role in the metabolism of endogenous chemical mediators, epoxyeicosatrienoic acids, which are involved in the regulation of blood pressure and inflammation. According to the pharmacophoric model suggested for sEH inhibitors, some new amide-based derivatives of 3-phenylglutaric acid were designed, synthesized and biologically evaluated. Docking study illustrated that the amide group as a primary pharmacophore had a suitable distance from the three amino acids of Tyr383, Tyr466 and Asp335 for effective hydrogen binding. Most of the compounds showed moderate to high sEH inhibitory activities in in vitro test in comparison with 12-(3-Adamantan-1-yl-ureido)-dodecanoic acid, as a potent urea-based sEH inhibitor. Compound 6o with phenethyl in R position exhibited the highest activity with IC50 value of 0.5?nM. Graphic abstract: In this study, some new amide-based derivatives of 3-phenylglutaric acid were designed, synthesized and biologically evaluated. Most of the synthesized compounds provided nanomolar range inhibition against sEH enzyme. The best observed IC50 value was 0.5?nM. Incorporating a carboxylic moiety into these structures by forming carboxylate salts would increase the solubility and improving physicochemical properties.[Figure not available: see fulltext.]

ALLOSTERIC PROTEIN KINASE MODULATORS

The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.