132786-97-1

Basic information

• Product Name: 4-thioxo-1,2,4,5-tetrahydro-6H-pyrazolo[3,4-d]pyrimidin-6-one
• CAS NO: 132786-97-1
• Molecular Formula: C₅H₄N₄OS
• Molecular Weight: 168.1765
• Mol File: 132786-97-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 374.2°C at 760 mmHg
• Flash Point: 180.1°C
• Density: 2.08g/cm³
• Vapor Pressure: 3.93E-06mmHg at 25°C
• Refractive Index: 2.019
• CAS DataBase Reference: 4-thioxo-1,2,4,5-tetrahydro-6H-pyrazolo[3,4-d]pyrimidin-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-thioxo-1,2,4,5-tetrahydro-6H-pyrazolo[3,4-d]pyrimidin-6-one(132786-97-1)
• EPA Substance Registry System: 4-thioxo-1,2,4,5-tetrahydro-6H-pyrazolo[3,4-d]pyrimidin-6-one(132786-97-1)

Safety Data

• Hazardous Substances Data: 132786-97-1(Hazardous Substances Data)

Upstream product

• 246855-09-4 N-benzylidene-N'-(6-chloro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazine 
• 246855-07-2 6-Chloro-4-hydrazino-1H-pyrazolo[3,4-d]pyrimidine 
• 50270-27-4 2,4,6-trichloropyrimidine-5-carbaldehyde 
• 110-86-1 pyridine 
• 2465-59-0 oxypurinol 
• 463-58-1 carbon oxide sulfide 
• 16617-46-2 3-amino-4-cyano-2H-pyrazole 

Downstream Products

• 5334-32-7 1⁽²⁾,7-dihydro-pyrazolo[3,4-d]pyrimidine-4,6-dithione 
• 6288-89-7 4,6-Bis-methylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine 
• 7251-92-5 6-chloro-N-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 

Relevant articles and documents

A General Route for the Facile Synthesis of 4-Thioxopyrimidin-2-one Derivatives via the Annulation of Cyclic o-Aminonitriles Using Carbonyl Sulfide

A facile synthesis of 4,5-diamino-9-(β-D-ribofuranosyl)pyrrolodipyrimidin-7-one (6) from an appropriately substituted pyrrolopyrimidine has been accomplished.A key reaction in this synthesis involves the ring closure of a cyclic o-aminonitrile precursor by using carbonyl sulfide to obtain the versatile 4-thioxopyrimidin-2-one intermediate 3.A study involving the generality of this reagent for the annulation of cyclic o-aminonitriles under different reaction conditions is also discussed.

Facile and general syntheses of 3- and/or 5-substituted 7H-pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidines as a new class of potential xanthine oxidase inhibitors

Convenient syntheses of 3- and/or 5-substituted 7H-pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidines as a new class of potent xanthine oxidase inhibitors, involving the oxidative cyclisation of 4-alkylidenehydrazino- or 4-arylmethylidenehydrazino-1H-pyrazolo[3,4-d]pyrimidines with 70% nitric acid as the key step, are described.