132797-27-4Relevant academic research and scientific papers
Stereoselective reactions. 30. Enantioselective alkylation of the lithium enolates of six-membered cyclic ketones using tetradentate chiral amines in the presence of lithium bromide
Murakata, Masatoshi,Yasukata, Tatsuro,Aoki, Takumi,Nakajima, Makoto,Koga, Kenji
, p. 2449 - 2458 (1998)
An efficient enantioselective alkylation of the lithium enolates of cyclohexanone and 1-tetralone with reactive alkyl halides was realized using a stoichiometric amount of a tetradentate chiral amine as a ligand for the lithium in the presence of lithium bromide in toluene.
Stereoselective reactions. Part 31: Catalytic asymmetric alkylation of achiral lithium enolates using a chiral tetradentate amine in the presence of an achiral bidentate amine
Imai, Mitsuko,Hagihara, Atsushi,Kawasaki, Hisashi,Manabe, Kei,Koga, Kenji
, p. 179 - 185 (2007/10/03)
Catalytic asymmetric alkylation of achiral lithium enolates of 1- tetralone and cyclohexanone with reactive alkyl halides was realized by using a combination of a chiral tetradentate amine (~0.05 equiv.) and an achiral bidentate amine (2 equiv.).
Enantioselective Alkylation at the α-Position of Cyclic Ketones using a Chiral Lithium Amide as a Base in the Presence of Lithium Bromide
Murakata, Masatoshi,Nakajima, Makoto,Koga, Kenji
, p. 1657 - 1658 (2007/10/02)
An efficient enantioselective alkylation reaction at the α-position of cyclic ketones (1, 2) can be realized in up to 92percent enantiomeric excess (e.e) by first forming their lithium enolates using a chiral lithium amide 4 in the presence of lithium bromide, followed by treatment with alkyl halides.
