132815-79-3

Upstream product

• 105-39-5 chloroacetic acid ethyl ester 
• 108-44-1 1-amino-3-methylbenzene 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 

Downstream Products

• 1144500-93-5 ethyl (2Z)-amino-[(3-methylphenyl)hydrazono]acetate 
• 1154103-26-0 C₁₁H₁₁N₃O₂ 
• 1190305-99-7 C₁₃H₁₃N₃O₄ 
• 1161946-86-6 ethyl 2,3,5,6-tetrahydro-8,9-dimethoxy-2-(2-(3-methylphenyl)hydrazono)-3-oxopyrrolo[2,1-a]isoquinoline-1-carboxylate 
• 204511-83-1 2-m-Tolyl-2H,5H-[1,2,4]triazolo[4,3-a]quinoxaline-1,4-dione 

Relevant academic research and scientific papers

Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists

Chemokine receptor 2 (CXCR2) is the receptor of glutamic acid–leucine–arginine sequence-contained chemokines CXCs (ELR+ CXCs). In recent years, CXCR2-target treatment strategy has come a long way in cancer therapy. CXCR2 antagonists could block

Optimization of non-ATP competitive CDK/cyclin groove inhibitors through REPLACE-mediated fragment assembly

A major challenge in drug discovery is to develop and improve methods for targeting protein-protein interactions. Further exemplification of the REPLACE (REplacement with Partial Ligand Alternatives through Computational Enrichment) strategy for generatin

PROCESSES FOR THE MANUFACTURE OF 3-{4-METHYL-5- [ (IR) -1- (2- (3-METHYLPHENYL) -2H-TETRAZOL-5-YL) -ETHOXY] -4H- [1,2, 4] TRIAZOL-3-YL} -PYRIDINE, 4-METHYL-3-METHYLTHIO-5- (3- PYRIDYL)-L,2,4-TRIAZOLE, AND (IR) -1- [2- (3-METHYLPHENYL) -2H- TETRAZOL-5-YL]

The present invention provides a process for the manufacture of the compound 3-{4-methyl-5-[(1R)-1-(2-(3-methylphenyl-2H-tetrazol-5-yl)-ethoxy]-4H-[1,2,4]triazol-3-yl}-pyridine of formula 14 wherein a) the compound 3-(5-methanesulfonyl-4-methyl-4H-1,2,4-t

SULPHIDE BRIDGED DERIVATIVES AS MODULATORS OF MGLUR5

The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

Kinetics and mechanism of dehydrochlorination of N-aryl-C-ethoxycarbonylformohydrazidoyl chlorides

The kinetics of triethylamine (TEA) catalyzed dehydrochlorination of a series of N-aryl-C-ethoxycarbonylformohydrazidoyl chlorides 1a-m have been studied under pseudo-first-order conditions in 4:1 (v/v) dioxane-water solution at 30 deg C.For all compounds