132843-73-3

Upstream product

• 6781-42-6 1,3-diacetylbenzene 
• 613-45-6 2,4-Dimethoxybenzaldehyde 

Downstream Products

• 143552-11-8 {3-[(1S,2R,3S)-2-(4-Chloro-benzenesulfonyl)-3-(2,4-dimethoxy-phenyl)-cyclopropanecarbonyl]-phenyl}-[(1S,2R,3S)-2-(4-chloro-benzenesulfonyl)-3-(2,4-dimethoxy-phenyl)-cyclopropyl]-methanone 
• 132843-95-9 {3-[4-(2,4-Dimethoxy-phenyl)-4,5-dihydro-1H-pyrazole-3-carbonyl]-phenyl}-[4-(2,4-dimethoxy-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-methanone 

Relevant academic research and scientific papers

Analogues of xanthones——Chalcones and bis-chalcones as α-glucosidase inhibitors and anti-diabetes candidates

Two series of compounds (chalcones and bis-chalcones) were designed, synthesized, and evaluated as α-glucosidase inhibitors (AGIs) with 1-deoxynojirimycin as positive control in vitro. Most of the compounds with two or four hydroxyl groups showed better inhibitory activities than 1-deoxynojirimycin towards α-glucosidase with noncompetitive mechanism. Moreover, most of the hydroxy bis-chalcones exhibit good α-glucosidase inhibitory activities in enzyme test. Inspiringly, bis-chalcones 2g (at 1 μM concentration) has stronger effect than 1-deoxynojirimycin on reducing the glucose level in HepG-2 cells (human liver cancer cell line).

Synthesis of New 2-Pyrazoline Derivatives From 2,6-Dicinnamoylpyridine And 1,3-Dicinnamoylbenzene

2,6-Dicinnamoylpyridine and 1,3-dicinnamoylbenzene react with hydrazines to yield 2-pyrazoline derivatives resulting from initial condensation with the carbonyl group in the acetyl compounds followed by a cyclization process.The structures of the synthesi