132843-73-3

Basic information

• Product Name: 2-Propen-1-one, 1,1'-(1,3-phenylene)bis[3-(2,4-dimethoxyphenyl)-, (E,E)-
• CAS NO: 132843-73-3
• Molecular Formula: C28H26O6
• Molecular Weight: 458.511
• Mol File: 132843-73-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1,1'-(1,3-phenylene)bis[3-(2,4-dimethoxyphenyl)-, (E,E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1,1'-(1,3-phenylene)bis[3-(2,4-dimethoxyphenyl)-, (E,E)-(132843-73-3)
• EPA Substance Registry System: 2-Propen-1-one, 1,1'-(1,3-phenylene)bis[3-(2,4-dimethoxyphenyl)-, (E,E)-(132843-73-3)

Safety Data

• Hazardous Substances Data: 132843-73-3(Hazardous Substances Data)

Upstream product

• 6781-42-6 1,3-diacetylbenzene 
• 613-45-6 2,4-Dimethoxybenzaldehyde 

Downstream Products

• 132843-95-9 {3-[4-(2,4-Dimethoxy-phenyl)-4,5-dihydro-1H-pyrazole-3-carbonyl]-phenyl}-[4-(2,4-dimethoxy-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-methanone 
• 143552-11-8 {3-[(1S,2R,3S)-2-(4-Chloro-benzenesulfonyl)-3-(2,4-dimethoxy-phenyl)-cyclopropanecarbonyl]-phenyl}-[(1S,2R,3S)-2-(4-chloro-benzenesulfonyl)-3-(2,4-dimethoxy-phenyl)-cyclopropyl]-methanone 

Relevant articles and documents

Analogues of xanthones——Chalcones and bis-chalcones as α-glucosidase inhibitors and anti-diabetes candidates

Two series of compounds (chalcones and bis-chalcones) were designed, synthesized, and evaluated as α-glucosidase inhibitors (AGIs) with 1-deoxynojirimycin as positive control in vitro. Most of the compounds with two or four hydroxyl groups showed better inhibitory activities than 1-deoxynojirimycin towards α-glucosidase with noncompetitive mechanism. Moreover, most of the hydroxy bis-chalcones exhibit good α-glucosidase inhibitory activities in enzyme test. Inspiringly, bis-chalcones 2g (at 1 μM concentration) has stronger effect than 1-deoxynojirimycin on reducing the glucose level in HepG-2 cells (human liver cancer cell line).