13287-78-0

Basic information

• Product Name: 2-(2-nitrophenyl)sulfanylethanol
• Synonyms: 2-[(2-Nitrophenyl)sulfanyl]ethanol; ethanol, 2-[(2-nitrophenyl)thio]-
• CAS NO: 13287-78-0
• Molecular Formula: C₈H₉NO₃S
• Molecular Weight: 199.23
• Mol File: 13287-78-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 345.6°C at 760 mmHg
• Flash Point: 162.8°C
• Density: 1.35g/cm³
• Vapor Pressure: 2.32E-05mmHg at 25°C
• Refractive Index: 1.621
• CAS DataBase Reference: 2-(2-nitrophenyl)sulfanylethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-nitrophenyl)sulfanylethanol(13287-78-0)
• EPA Substance Registry System: 2-(2-nitrophenyl)sulfanylethanol(13287-78-0)

Safety Data

• Hazardous Substances Data: 13287-78-0(Hazardous Substances Data)

Upstream product

• 24290-27-5 (2-nitro-phenylsulfanyl)-acetic acid ethyl ester 
• 1493-27-2 ortho-nitrofluorobenzene 
• 60-24-2 2-hydroxyethanethiol 
• 88-73-3 2-Chloronitrobenzene 
• 577-19-5 2-nitrophenyl bromide 

Downstream Products

• 13290-56-7 (2-bromo-ethyl)-(2-nitro-phenyl)-sulfide 
• 62047-27-2 (2-chloro-ethyl)-(2-nitro-phenyl)-sulfide 
• 88543-37-7 2-(2-nitro-benzenesulfinyl)-ethanol 
• 21386-33-4 2-(2-nitro-benzenesulfonyl)-ethanol 
• 63343-13-5 1-((2-chloroethyl)sulfonyl)-2-nitrobenzene 
• 88-75-5 2-hydroxynitrobenzene 
• 77474-06-7 2-<(2-Hydroxyethyl)thio>aniline 
• 71532-95-1 C₁₄H₁₂N₂O₄S₂ 
• 71532-96-2 1,2-di(o-nitrophenolthio)ethane 

Relevant articles and documents

Design, synthesis and biological evaluation N2-(2-alkyoxy-6-aliphatic aminopyridin-3-yl)-2,4-diaminepyrimidine derivatives bearing acylamino or DBTD ‘head’ as potential ALK inhibitors

Aiming to develop promising ALK inhibitors, two series of N2-(2-alkyoxy-6-aliphatic aminopyridin-3-yl)-2,4-diaminepyrimidine derivatives (22a-x and 23a-d) were designed according to scaffold hopping and bioisosterism principles. All compounds were efficiently synthesized by concise reactions and anti-proliferative activities on ALK-addicted H2228, Karpas299 cells and EGFR-expressive A549 cell were evaluated by MTT assay. Several compounds exhibited potential cytotoxic activities with IC50 values below 0.10 μM. Five compounds (22g, 22h, 22l, 22s and 23a) were selected for further enzymatic determination, resulting in the discovery of 22l against ALK and ALKL1196M with IC50 values of 2.1 nM and 3.8 nM. Particularly, western blot and cell apoptosis assays identified 22l as a promising ALK inhibitor, which was capable of obviously inhibiting cellular ALK activity and inducing cell apoptosis. Eventually, molecular docking modes of 22l with ALK confirmed structural basis in accordance with the SARs analysis.

Process for producing aminophenyl-β-hydroxyethylsulfone

A process for producing aminophenyl-β-hydroxyethylsulfone of the formula (I), STR1 which comprises the following steps: (1) condensing nitrohalobenzene with mercaptoethanol in the presence of an alkali hydroxide and at least one reaction medium selected from N-alkyl-substituted amides and sulfoxides to produce mononitrophenyl-β-hydroxyethylsulfide of the formula (II): STR2 (2) oxidizing the mononitrophenyl-β-hydroxyethylsulfide (II) to produce mononitrophenyl-β-hydroxyethylsulfone of the formula (III): STR3 and (3) reducing the mononitrophenyl-β-hydroxyethylsulfone to produce the aminophenyl-β-hydroxyethylsulfone of the formula (I). This compound is useful as an intermediate for aminophenyl-β-sulfatoethylsulfone represented by the following formula: STR4 which is an important intermediate for vinyl sulfone type reactive dyes largely used for dyeing cellulose fiber materials.