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Upstream product

• 15443-94-4 (6,7-dimethoxyisoquinolin-1-yl)(2-nitrophenyl)methanone 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 412337-64-5 6,7-dimethoxy-1-(2-nitro-benzyl)-3,4-dihydro-isoquinoline 
• 4230-93-7 3,4-dimethoxynitrostyrene 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 
• 22751-23-1 (2-nitrophenyl)acetyl chloride 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 351155-99-2 N-(2-(3,4-dimethoxyphenyl)ethyl)-2-(2-nitrophenyl)acetamide 

Relevant academic research and scientific papers

Novel total syntheses of oxoaporphine alkaloids enabled by mild Cu-catalyzed tandem oxidation/aromatization of 1-Bn-DHIQs

Novel total syntheses of oxoaporphine alkaloids such as liriodenine, dicentrinone, cassameridine, lysicamine, oxoglaucine and O-methylmoschatoline were developed. The key step of these total syntheses is Cu-catalyzed conversion of 1-benzyl-3,4-dihydro-isoquinolines (1-Bn-DHIQs) to 1-benzoyl-isoquinolines (1-Bz-IQs) via tandem oxidation/aromatization. This novel Cu-catalyzed conversion has been studied in detail, and was successfully used for constructing the 1-Bz-IQ core.